MYCBP c-myc binding protein [Homo sapiens] - Gene

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Summary

Official Symbol: MYCBPprovided by HGNC
Official Full Name: c-myc binding proteinprovided by HGNC
Primary source: HGNC:7554
See related: Ensembl:ENSG00000214114; HPRD:08406; MIM:606535; Vega:OTTHUMG00000000484
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AMY-1; FLJ41056
Summary: The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

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Genomic context

Location :: 1p33-p32.2

Sequence :: Chromosome: 1; NC_000001.10 (39328162..39339050, complement)

See MYCBP in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

c-Myc expression is reduced in pterygium compared with normal conjunctiva.
Title: Downregulation of c-Myc in pterygium and cultured pterygial cells.
Suppression of telomerase activity mediated by PinX1 is involved in the Mad1/c-Myc pathway.
Title: PinX1 inhibits telomerase activity in gastric cancer cells through Mad1/c-Myc pathway.
miR-22 acts as a tumor suppressor through direct repression of MYCBP expression and subsequent reduction of oncogenic c-Myc activities.
Title: Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
An important role for MBP-1 in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration.
Title: c-myc promoter binding protein regulates the cellular response to an altered glucose concentration.
identified a novel AMY-1-binding protein, AAT-1, and determied its expression profiles, genes, and cellular localization; results showed that AAT-1 was specifically expressed in the testis throughout spermatogenesis and was also present in mature sperm
Title: AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase.
interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits enzyme acdtivity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex
Title: AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.
AMY-1 coordinates ADP-Ribosylation Factors-mediated membrane trafficking and signaling pathways.
Title: AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.
AMY-1 was localized in the mitochondria of HeLa and sperm in association with AKAP149 and S-AKAP84, respectively. These results suggest that AMY-1 plays a role in spermatogenesis
Title: AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q99417	Q92667	AKAP1	HPRD	PubMed
Q99417	Hypothetical protein FLJ10357	ARHGEF40	HPRD	PubMed
Q99417	Q7Z4T9	C3orf15	HPRD	PubMed
Q99417	P23528	CFL1	HPRD	PubMed
Q99417	Q7L5N1	COPS6	HPRD	PubMed
Q99417	Q99829	CPNE1	HPRD	PubMed
Q99417	Q96FN4	CPNE2	HPRD	PubMed
Q99417	Q96A23	CPNE4	HPRD	PubMed
Q99417	O60383	GDF9	HPRD	PubMed
Q99417	P01106	MYC	HPRD	PubMed
Q99417	AMAP 1	MYCBPAP	HPRD	PubMed
Q99417	Patched domain containing 2	PTCHD2	HPRD	PubMed
Q99417	P21246	PTN	HPRD	PubMed
Q99417	Q08945	SSRP1	HPRD	PubMed
BioGRID:117673	BioGRID:113818	AKAP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:117673	BioGRID:120826	ARHGEF40	BioGRID	PubMed	Two-hybrid
BioGRID:117673	BioGRID:124630	C3orf15	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:117673	BioGRID:107499	CFL1	BioGRID	PubMed	Two-hybrid
BioGRID:117673	BioGRID:116176	COPS6	BioGRID	PubMed	Two-hybrid
BioGRID:117673	BioGRID:206280	D2Ertd750e	BioGRID	PubMed	Affinity Capture-MS
BioGRID:117673	BioGRID:128178	EIF2C4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:117673	BioGRID:108930	GDF9	BioGRID	PubMed	Two-hybrid
BioGRID:117673	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:117673	BioGRID:123868	MYCBPAP	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:117673	BioGRID:120112	OTUD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:117673	BioGRID:121599	PTCHD2	BioGRID	PubMed	Two-hybrid
BioGRID:117673	BioGRID:111731	PTN	BioGRID	PubMed	Two-hybrid
BioGRID:117673	BioGRID:112627	SSRP1	BioGRID	PubMed	Two-hybrid
BioGRID:117673	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: C-Myc-binding protein

Names: C-Myc-binding protein; associate of myc-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012333.4 → NP_036465.2 C-Myc-binding protein

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.

Source sequence(s)

AL139260, BC008686, BU601195, CN478752

Consensus CDS

CCDS431.1

UniProtKB/Swiss-Prot

Q99417

Related

ENSP00000380702, OTTHUMP00000000543, ENST00000397572, OTTHUMT00000001209

RNA

NR_037632.1 RNA Sequence

Description

Transcript Variant: This variant (2) lacks an alternate internal exon and uses an alternate splice site compared to variant 1. The transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it does not meet quality criteria. As such there is uncertainty about the protein-coding capacity of the transcript.

Source sequence(s)

AL139260, BQ437941, BU601195, CN478752

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

39328162..39339050, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

37446340..37457235, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL139260.19	CAI23050.1
genomic	CH471059.2	EAX07290.1
		EAX07291.1
		EAX07292.1
mRNA	AB007191.2	BAA22408.1
mRNA	AB451287.1	BAG70101.1
mRNA	AB451419.1	BAG70233.1
mRNA	AK311886.1	BAG34827.1
mRNA	BC008686.1	AAH08686.1
mRNA	BE502732.1	None
mRNA	BQ437941.1	None
mRNA	BT007109.1	AAP35773.1
mRNA	BU601195.1	None
mRNA	CN478752.1	None
mRNA	CR456936.1	CAG33217.1
mRNA	D50692.1	BAA09338.1
other-genetic	DQ891491.2	ABM82417.1
other-genetic	DQ893698.2	ABM84624.1
other-genetic	DQ894690.2	ABM85616.1