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AK5 adenylate kinase 5 [ Homo sapiens (human) ]

Gene ID: 26289, updated on 26-May-2016
Official Symbol
AK5provided by HGNC
Official Full Name
adenylate kinase 5provided by HGNC
Primary source
HGNC:HGNC:365
See related
Ensembl:ENSG00000154027 HPRD:10472; MIM:608009; Vega:OTTHUMG00000009796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AK6
Summary
This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p31
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (77281977..77559969)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (77747662..78025654)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class K Neighboring gene alanyl-tRNA synthetase domain containing 1 pseudogene Neighboring gene uncharacterized LOC105378808 Neighboring gene uncharacterized LOC105378809 Neighboring gene RNA, U7 small nuclear 8 pseudogene Neighboring gene zinc finger ZZ-type containing 3 Neighboring gene RNA, 5S ribosomal pseudogene 20 Neighboring gene ubiquitin specific peptidase 33

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of adenylate kinase 5 (AK5) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC33326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside kinase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
ADP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
dADP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleoside diphosphate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside triphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
pyrimidine ribonucleotide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 
Preferred Names
adenylate kinase isoenzyme 5
Names
AK 5
ATP-AMP transphosphorylase 5
adenylate kinase 6
NP_036225.2
NP_777283.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012093.3NP_036225.2  adenylate kinase isoenzyme 5 isoform 2

    See identical proteins and their annotated locations for NP_036225.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate and longer first exon which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AW665223, BC012467, BC033896, BC036666, DN993295
    Consensus CDS
    CCDS676.1
    UniProtKB/Swiss-Prot
    Q9Y6K8
    Related
    ENSP00000341430, OTTHUMP00000011354, ENST00000344720, OTTHUMT00000026992
    Conserved Domains (2) summary
    TIGR01360
    Location:348535
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:352524
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  2. NM_174858.2NP_777283.1  adenylate kinase isoenzyme 5 isoform 1

    See identical proteins and their annotated locations for NP_777283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript yet it encodes the longer protein (isoform 1).
    Source sequence(s)
    AF445193, AW665223, BC036666
    Consensus CDS
    CCDS675.1
    UniProtKB/Swiss-Prot
    Q9Y6K8
    Related
    ENSP00000346577, OTTHUMP00000011355, ENST00000354567, OTTHUMT00000026993
    Conserved Domains (2) summary
    TIGR01360
    Location:374561
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:378550
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    77281977..77559969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270739.3XP_005270796.1  

    See identical proteins and their annotated locations for XP_005270796.1

    Conserved Domains (2) summary
    TIGR01360
    Location:350537
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:354526
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
  2. XM_006710572.2XP_006710635.1  

    See identical proteins and their annotated locations for XP_006710635.1

    UniProtKB/Swiss-Prot
    Q9Y6K8
    Conserved Domains (2) summary
    TIGR01360
    Location:348535
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
    cd01428
    Location:352524
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    77863034..78141541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)