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    FBXO8 F-box protein 8 [ Homo sapiens ]

    Gene ID: 26269, updated on 11-May-2012
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    Summary

    Official Symbol
    FBXO8provided by HGNC
    Official Full Name
    F-box protein 8provided by HGNC
    Primary source
    HGNC:13587
    Locus tag
    DC10
    See related
    Ensembl:ENSG00000164117; HPRD:07293; MIM:605649; Vega:OTTHUMG00000160746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBS; DC10; FBX8
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4q34.1
    Sequence :
    Chromosome: 4; NC_000004.11 (175157809..175205402, complement)
    See FBXO8 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene RAN, member RAS oncogene family pseudogene 6 Neighboring gene uncharacterized LOC100506154 Neighboring gene centrosomal protein 44kDa Neighboring gene microRNA 4276 Neighboring gene hydroxyprostaglandin dehydrogenase 15-(NAD)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. c-Myc stimulates cell invasion by inhibiting FBX8 function. Cho HJ, et al. Mol Cells, 2010 Oct. PMID 20848231.
    2. Screening for replication of genome-wide SNP associations in sporadic ALS. Cronin S, et al. Eur J Hum Genet, 2009 Feb. PMID 18987618.
    3. Fbx8 makes Arf6 refractory to function via ubiquitination. Yano H, et al. Mol Biol Cell, 2008 Mar. PMID 18094045.
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965.

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. FBX8 is a novel c-Myc binding protein and that c-Myc induces cell invasive activity
      Title: c-Myc stimulates cell invasion by inhibiting FBX8 function.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Screening for replication of genome-wide SNP associations in sporadic ALS.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NRD0 P63208 SKP1    HPRD  PubMed  
    BioGRID:117653 BioGRID:106877 ARF6    BioGRID  PubMed Biochemical Activity; Co-localization 
    BioGRID:117653 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117653 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117653 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117653 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ARF guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    ARF guanyl-nucleotide exchange factor activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    F-box only protein 8
    Names
    F-box only protein 8
    F-box protein Fbx8
    F-box/SEC7 protein FBS
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012180.2 → NP_036312.2  F-box only protein 8

      Status: REVIEWED

      Source sequence(s)
      AF115514, BC014903
      Consensus CDS
      CCDS3820.1
      UniProtKB/TrEMBL
      Q8IXA8
      UniProtKB/Swiss-Prot
      Q9NRD0
      Related
      ENSP00000377280, OTTHUMP00000218882, ENST00000393674, OTTHUMT00000362085
      Conserved Domains (2) summary
      cd00171
      Location:133 – 312
      Blast Score: 391
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cl02535
      Location:74 – 112
      Blast Score: 127
      F-box; F-box domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      175157809..175205402, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      170904173..170951800, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC097653.2 (51311..98904) None
    genomic CH471056.2 EAX04741.1
      EAX04742.1
      EAX04743.1
      EAX04744.1
      EAX04745.1
    mRNA AF115514.1 AAO06951.1
    mRNA AF174596.1 AAF04517.1
    mRNA AF201932.1 AAF86868.1
    mRNA AF233224.1 AAF67154.1
    mRNA AK026319.1 None
    mRNA AK123740.1 BAG53949.1
    mRNA AK314483.1 BAG37087.1
    mRNA AL602916.1 None
    mRNA AY358721.1 AAQ89083.1
    mRNA BC014679.2 AAH14679.1
    mRNA BC014903.1 None
    mRNA BC040456.1 AAH40456.1
    other-genetic HQ447833.1 ADQ32317.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWE1 GenPept UniProtKB/TrEMBL:Q8IWE1
    Q8IXA8 GenPept UniProtKB/TrEMBL:Q8IXA8
    Q9NRD0.1 GenPept UniProtKB/Swiss-Prot:Q9NRD0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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