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FBXO9 F-box protein 9 [ Homo sapiens (human) ]

Gene ID: 26268, updated on 8-May-2016
Official Symbol
FBXO9provided by HGNC
Official Full Name
F-box protein 9provided by HGNC
Primary source
HGNC:HGNC:13588
See related
Ensembl:ENSG00000112146 HPRD:16434; MIM:609091; Vega:OTTHUMG00000014869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX9; VCIA1; NY-REN-57; dJ341E18.2
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6p12.3-p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (53057783..53100873)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52922586..52965671)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase alpha 4 Neighboring gene RNA, 7SK small nuclear Neighboring gene intestinal cell (MAK-like) kinase Neighboring gene uncharacterized LOC105375092 Neighboring gene uncharacterized LOC105375093 Neighboring gene glial cells missing homolog 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0936, DKFZp434C0118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
F-box only protein 9
Names
F-box protein Fbx9
cross-immune reaction antigen 1
renal carcinoma antigen NY-REN-57

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012347.4NP_036479.1  F-box only protein 9 isoform 1

    See identical proteins and their annotated locations for NP_036479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is shortest transcript yet it encodes the longest protein (isoform 1).
    Source sequence(s)
    AF176704, AL031178, BC000650
    Consensus CDS
    CCDS55023.1
    UniProtKB/Swiss-Prot
    Q9UK97
    Related
    ENSP00000244426, OTTHUMP00000016628, ENST00000244426, OTTHUMT00000040950
    Conserved Domains (2) summary
    pfam12937
    Location:188239
    F-box-like; F-box-like
    cl00299
    Location:91123
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  2. NM_033480.2NP_258441.1  F-box only protein 9 isoform 2

    See identical proteins and their annotated locations for NP_258441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different segment for the 5' UTR and 5' coding region, compared to variant 1. It uses a different translation start codon and the encoded protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL031178, AL137520
    Consensus CDS
    CCDS55022.1
    UniProtKB/Swiss-Prot
    Q9UK97
    Related
    ENSP00000326968, OTTHUMP00000016629, ENST00000323557, OTTHUMT00000040951
    Conserved Domains (2) summary
    pfam12937
    Location:178229
    F-box-like; F-box-like
    cl00299
    Location:81113
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  3. NM_033481.3NP_258442.2  F-box only protein 9 isoform 3

    See identical proteins and their annotated locations for NP_258442.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different segment for the 5' UTR and lacks part of the 5' coding region, compared to variant 1. It uses a downstream translation start codon, with the resulting protein (isoform 3) having a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL031178, BC000650
    Consensus CDS
    CCDS55024.1
    UniProtKB/Swiss-Prot
    Q9UK97
    Related
    ENSP00000359977, OTTHUMP00000214588, ENST00000370939, OTTHUMT00000354211
    Conserved Domains (2) summary
    pfam12937
    Location:144195
    F-box-like; F-box-like
    cl00299
    Location:4779
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    53057783..53100873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248995.3XP_005249052.1  

    See identical proteins and their annotated locations for XP_005249052.1

    UniProtKB/Swiss-Prot
    Q9UK97
    Conserved Domains (2) summary
    pfam12937
    Location:144195
    F-box-like; F-box-like
    cl00299
    Location:4779
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  2. XM_011514464.1XP_011512766.1  

    See identical proteins and their annotated locations for XP_011512766.1

    UniProtKB/Swiss-Prot
    Q9UK97
    Conserved Domains (2) summary
    pfam12937
    Location:144195
    F-box-like; F-box-like
    cl00299
    Location:4779
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  3. XM_005248996.3XP_005249053.1  

    See identical proteins and their annotated locations for XP_005249053.1

    UniProtKB/Swiss-Prot
    Q9UK97
    Conserved Domains (2) summary
    pfam12937
    Location:144195
    F-box-like; F-box-like
    cl00299
    Location:4779
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    52931587..52967433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)