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FBXO24 F-box protein 24 [ Homo sapiens (human) ]

Gene ID: 26261, updated on 8-May-2016
Official Symbol
FBXO24provided by HGNC
Official Full Name
F-box protein 24provided by HGNC
Primary source
HGNC:HGNC:13595
See related
Ensembl:ENSG00000106336 HPRD:16438; MIM:609097; Vega:OTTHUMG00000159543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX24
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Orthologs
Location:
7q22
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (100586333..100601117)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100183840..100198740)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sin3A associated protein 25kDa Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 4 Neighboring gene ZO-2 associated speckle protein Neighboring gene PCOLCE antisense RNA 1 Neighboring gene procollagen C-endopeptidase enhancer Neighboring gene motile sperm domain containing 3

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp434I1122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
F-box only protein 24
Names
F-box protein Fbx24

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163499.1NP_001156971.1  F-box only protein 24 isoform 4

    See identical proteins and their annotated locations for NP_001156971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK302252, BC067293
    Consensus CDS
    CCDS55138.1
    UniProtKB/Swiss-Prot
    O75426
    Related
    ENSP00000420239, OTTHUMP00000215773, ENST00000468962, OTTHUMT00000356108
    Conserved Domains (2) summary
    pfam00415
    Location:364410
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:3173
    F-box-like; F-box-like
  2. NM_012172.4NP_036304.2  F-box only protein 24 isoform 3

    See identical proteins and their annotated locations for NP_036304.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter, 5' UTR, and 5' coding region, compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK301864, BC067293, DC397982
    Consensus CDS
    CCDS5699.2
    UniProtKB/Swiss-Prot
    O75426
    Related
    ENSP00000416558, OTTHUMP00000215774, ENST00000427939, OTTHUMT00000356109
    Conserved Domains (2) summary
    pfam00415
    Location:414460
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:81123
    F-box-like; F-box-like
  3. NM_033506.2NP_277041.1  F-box only protein 24 isoform 1

    See identical proteins and their annotated locations for NP_277041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    BC067293, BU656991
    Consensus CDS
    CCDS5698.1
    UniProtKB/Swiss-Prot
    O75426
    UniProtKB/TrEMBL
    A4D2D3
    Related
    ENSP00000241071, OTTHUMP00000215770, ENST00000241071, OTTHUMT00000356104
    Conserved Domains (2) summary
    pfam00415
    Location:376422
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:4385
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    100586333..100601117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516022.1XP_011514324.1  

    Conserved Domains (2) summary
    pfam00415
    Location:381427
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:4890
    F-box-like; F-box-like
  2. XM_005250259.2XP_005250316.1  

    Conserved Domains (2) summary
    pfam00415
    Location:414443
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam12937
    Location:81123
    F-box-like; F-box-like
  3. XM_011516023.1XP_011514325.1  

    Conserved Domains (1) summary
    pfam00415
    Location:208254
    RCC1; Regulator of chromosome condensation (RCC1) repeat

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    100114528..100129312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)