NKX2-8 NK2 homeobox 8 [Homo sapiens] - Gene

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Summary

Official Symbol: NKX2-8provided by HGNC
Official Full Name: NK2 homeobox 8provided by HGNC
Primary source: HGNC:16364
See related: Ensembl:ENSG00000136327; HPRD:04456; MIM:603245; Vega:OTTHUMG00000028772
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NKX2H; NKX2.8; Nkx2-9

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Genomic context

Location :: 14q13.3

Sequence :: Chromosome: 14; NC_000014.8 (37049216..37051786, complement)

See NKX2-8 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Most tumors have low expression of Nkx2-8, and its expression can inhibit growth of some lung cancer cells.
Title: Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.
Coactivation of the TTF-1 and NKX2-8 pathways identified a cluster of lung cancer patients with poor survival and were shown to exhibit resistance to cisplatin
Title: Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.
A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor.
Title: Regulation of alpha-fetoprotein expression by Nkx2.8.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
O15522	O15522	NKX2-8		HPRD	PubMed

Function	Evidence Code	Pubs
double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
axonogenesis	IEA Inferred from Electronic Annotation more info
liver development	NAS Non-traceable Author Statement more info	PubMed
lung development	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: homeobox protein Nkx-2.8

Names: homeobox protein Nkx-2.8; NK-2 homolog 8; NK-2 homolog H; homeobox protein NK-2 homolog H; NK2 transcription factor related, locus 8

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014360.2 → NP_055175.2 homeobox protein Nkx-2.8

Status: PROVISIONAL

Source sequence(s)

BC041090

Consensus CDS

CCDS9660.1

UniProtKB/Swiss-Prot

O15522

Related

ENSP00000258829, OTTHUMP00000027959, ENST00000258829, OTTHUMT00000071844

Conserved Domains (1) summary

cd00086
Location:85 – 141
Blast Score: 174

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

37049216..37051786, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

17163843..17166413, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF000297.1	AAC71082.1
genomic	AL079303.3 (17625..20195)	None
mRNA	AF000295.1	AAC71081.1
mRNA	AK313537.1	BAG36314.1
mRNA	BC041090.1	AAH41090.1