STAP1 signal transducing adaptor family member 1 [Homo sapiens] - Gene

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Summary

Official Symbol: STAP1provided by HGNC
Official Full Name: signal transducing adaptor family member 1provided by HGNC
Primary source: HGNC:24133
See related: Ensembl:ENSG00000035720; HPRD:16053; MIM:604298; Vega:OTTHUMG00000129304
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BRDG1; STAP-1
Summary: The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 4q13.2

Sequence :: Chromosome: 4; NC_000004.11 (68424446..68472616)

See STAP1 in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.

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Products	Interactant	Other Gene	Source	Pubs	Description
BCR downstream signaling 1	P10721	KIT	HPRD	PubMed
BCR downstream signaling 1	Q14289	PTK2B	HPRD	PubMed
BCR downstream signaling 1	P42680	TEC	HPRD	PubMed
BCR downstream signaling 1	O94763	URI1	HPRD	PubMed
BioGRID:117619	BioGRID:111224	PFDN2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:117619	BioGRID:111225	PFDN4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:117619	BioGRID:111430	POLR2E	BioGRID	PubMed	Affinity Capture-MS
BioGRID:117619	BioGRID:114166	RUVBL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:117619	BioGRID:116067	RUVBL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:117619	BioGRID:114264	URI1	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex

Function	Evidence Code	Pubs
SH3/SH2 adaptor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cellular membrane fusion	TAS Traceable Author Statement more info	PubMed
intracellular protein transport	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
intracellular	TAS Traceable Author Statement more info	PubMed
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: signal-transducing adaptor protein 1

Names: signal-transducing adaptor protein 1; docking protein BRDG1; BCR downstream signaling 1; stem cell adaptor protein 1; BCR downstream-signaling protein 1; signal-transducing adaptor protein-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012108.2 → NP_036240.1 signal-transducing adaptor protein 1

Status: REVIEWED

Source sequence(s)

AB023483, BG190230

Consensus CDS

CCDS3515.1

UniProtKB/Swiss-Prot

Q9ULZ2

Related

ENSP00000265404, OTTHUMP00000159639, ENST00000265404, OTTHUMT00000251434

Conserved Domains (2) summary

cd10403
Location:176 – 268
Blast Score: 462

SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)

cl00273
Location:28 – 112
Blast Score: 81

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p5 Primary Assembly

Range

68424446..68472616

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

64337610..64385777

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC096720.3	AAY40998.1
genomic	AC109356.3 (20994..61577)	None
genomic	CH471057.1	EAX05547.1
		EAX05548.1
mRNA	AB023483.1	BAA85311.1
mRNA	AK313676.1	BAG36427.1
mRNA	BC014958.1	AAH14958.1
mRNA	BG190230.1	None
other-genetic	HQ447234.1	ADQ31721.1