These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_011432.1 RefSeqGene
- Range
- 5001..62943
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001193431.1 → NP_001180360.1 tyrosine-protein phosphatase non-receptor type 22 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
- Source sequence(s)
-
AA836401, AK303124, AL137856, DB145424, GU479452
- UniProtKB/TrEMBL
-
B4DZW8
- UniProtKB/Swiss-Prot
-
Q9Y2R2
- Conserved Domains (2) summary
-
- cd00047
Location:56 – 288
Blast Score: 785
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- smart00194
Location:24 – 288
Blast Score: 881
- PTPc; Protein tyrosine phosphatase, catalytic domain
-
NM_012411.4 → NP_036543.4 tyrosine-protein phosphatase non-receptor type 22 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
- Source sequence(s)
-
AA836401, AL137856, BC071670, DB145424
- Consensus CDS
-
CCDS864.2
- UniProtKB/Swiss-Prot
-
Q9Y2R2
- Related
- ENSP00000435176, OTTHUMP00000013721, ENST00000528414, OTTHUMT00000033018
- Conserved Domains (1) summary
-
- cd00047
Location:56 – 252
Blast Score: 691
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
-
NM_015967.5 → NP_057051.3 tyrosine-protein phosphatase non-receptor type 22 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
AA836401, AF077031, AK303124, AL137856, DB145424
- Consensus CDS
-
CCDS863.1
- UniProtKB/TrEMBL
-
B4DZW8
- UniProtKB/Swiss-Prot
-
Q9Y2R2
- Related
- ENSP00000352833, OTTHUMP00000013720, ENST00000359785, OTTHUMT00000033015
- Conserved Domains (2) summary
-
- cd00047
Location:56 – 288
Blast Score: 788
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- smart00194
Location:24 – 288
Blast Score: 884
- PTPc; Protein tyrosine phosphatase, catalytic domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000001.10 Reference GRCh37.p5 Primary Assembly
- Range
- 114356433..114414375, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000133.1 Alternate HuRef
- Range
- 112214556..112272493, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)