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    INTS1 integrator complex subunit 1 [ Homo sapiens ]

    Gene ID: 26173, updated on 11-May-2012
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    Summary

    Official Symbol
    INTS1provided by HGNC
    Official Full Name
    integrator complex subunit 1provided by HGNC
    Primary source
    HGNC:24555
    Locus tag
    UNQ1821/PRO3434
    See related
    Ensembl:ENSG00000164880; MIM:611345; Vega:OTTHUMG00000151449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT1; NET28; FLJ46624; KIAA1440; DKFZp586J0619
    Summary
    INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    7p22.3
    Sequence :
    Chromosome: 7; NC_000007.13 (1509913..1544018, complement)
    See INTS1 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene UNC homeobox Neighboring gene MICAL-like 2 Neighboring gene uncharacterized LOC100128653 Neighboring gene transmembrane protein 184A Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Purification and identification of endogenous polySUMO conjugates. Bruderer R, et al. EMBO Rep, 2011 Feb. PMID 21252943.

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Integrator complex subunit 1 O75398 DEAF1    HPRD  PubMed  
    BioGRID:117596 BioGRID:120846 ASUN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:123520 C15orf44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:122499 C7orf26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:120310 CPSF3L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:114597 CTDP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117596 BioGRID:128475 DDX26B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:117596 INTS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:120473 INTS10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:121381 INTS12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:121572 INTS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:122401 INTS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:124909 INTS4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:123312 INTS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:117717 INTS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:117404 INTS7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:120788 INTS8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:120874 INTS9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:122500 OBFC2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:111427 POLR2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:111433 POLR2H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:111494 PPP1CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:111511 PPP2R1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:122959 RPAP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:122783 RPAP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:112779 TCEA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:117146 ZMYND8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117596 BioGRID:121643 ZNF687    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    U2 snRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    inner cell mass cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    snRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    integrator complex subunit 1
    Names
    integrator complex subunit 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080453.2 → NP_001073922.2  integrator complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      AB037861, AI935093, BC069262, BF346658, BM547069, BM553299, BX324321, DB113520
      Consensus CDS
      CCDS47526.1
      UniProtKB/Swiss-Prot
      Q8N201
      Related
      ENSP00000385722, OTTHUMP00000200439, ENST00000404767, OTTHUMT00000323683
      Conserved Domains (1) summary
      pfam12432
      Location:350 – 430
      Blast Score: 273
      DUF3677; Protein of unknown function (DUF3677)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      1509913..1544018, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      1430650..1464808, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      1562263..1596426, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC093734.3 None
    genomic AC102953.5 (123692..146995) None
    genomic CH236953.1 EAL23941.1
      EAL23942.1
    mRNA AB037861.1 BAA92678.1
    mRNA AI935093.1 None
    mRNA AK128368.1 None
    mRNA AL050110.1 CAB43278.2
    mRNA AL137358.1 CAB70710.3
    mRNA AY358482.1 AAQ88846.1
    mRNA BC004286.1 AAH04286.1
    mRNA BC013367.2 AAH13367.2
    mRNA BC018777.1 AAH18777.1
    mRNA BC069262.1 AAH69262.1
    mRNA BF346658.1 None
    mRNA BK005720.1 DAA05720.1
    mRNA BM547069.1 None
    mRNA BM553299.1 None
    mRNA BX324321.2 None
    mRNA DB113520.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N201.2 GenPept UniProtKB/Swiss-Prot:Q8N201
    Q9BT91 GenPept UniProtKB/TrEMBL:Q9BT91
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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