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    SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 [ Homo sapiens ]

    Gene ID: 26168, updated on 11-May-2012
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    Summary

    Official Symbol
    SENP3provided by HGNC
    Official Full Name
    SUMO1/sentrin/SMT3 specific peptidase 3provided by HGNC
    Primary source
    HGNC:17862
    See related
    Ensembl:ENSG00000161956; HPRD:08339; MIM:612844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSP3; Ulp1; SMT3IP1; DKFZp762A152; DKFZp586K0919
    Summary
    The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
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    Genomic context

    Location :
    17p13
    Sequence :
    Chromosome: 17; NC_000017.10 (7465309..7475287)
    See SENP3 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene TNFSF12-TNFSF13 readthrough Neighboring gene tumor necrosis factor (ligand) superfamily, member 12 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13 Neighboring gene SENP3-EIF4A1 readthrough Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene small nucleolar RNA, H/ACA box 48 Neighboring gene small nucleolar RNA, C/D box 10

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. PIDD orchestrates translesion DNA synthesis in response to UV irradiation. Logette E, et al. Cell Death Differ, 2011 Jun. PMID 21415862.
    3. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Huang W, et al. Nature, 2011 Feb 17. PMID 21331046.
    4. The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation. Nishida T, et al. Biochem Biophys Res Commun, 2011 Mar 11. PMID 21316347.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (43) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These results suggest that SMT3IP1 is a new regulator of the p53-Mdm2 pathway.
      Title: The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation.
    2. Hsp90/SENP3 association protects SENP3 from CHIP-mediated ubiquitination and subsequent degradation, but this effect of Hsp90 requires the presence of CHIP.
      Title: Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
    5. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress.
      Title: SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress.
    6. Results demonstrate that SENP1 is the most efficient SUMO protease acting on Elk-1, and that SENP3 has little effect on Elk-1. SENP2 has an intermediate effect, but its ability to activate Elk-1 is independent from its SUMO-deconjugating activity.
      Title: SENP1 participates in the dynamic regulation of Elk-1 SUMOylation.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Risk of meningioma and common variation in genes related to innate immunity.
    8. SENP3 is a redox sensor that regulates HIF-1 transcriptional activity under oxidative stress through the de-SUMOylation of p300
      Title: SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.
    9. Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway.
      Title: RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.
    10. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
      Title: Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
    Submit: New GeneRIF Correction See all (12)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H4L4 Activating transcription factor 7 interacting protein ATF7IP    HPRD  PubMed  
    Q9H4L4 Q09472 EP300    HPRD  PubMed  
    Q9H4L4 P61956 SUMO2    HPRD  PubMed  
    BioGRID:117594 BioGRID:109337 HIC1    BioGRID  PubMed Biochemical Activity 
    BioGRID:117594 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117594 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:117594 BioGRID:110373 MEF2D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117594 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:117594 BioGRID:113222 NR1H2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117594 BioGRID:106652 PARP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:117594 BioGRID:117973 PELP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117594 BioGRID:120645 PIDD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117594 BioGRID:112094 RPLP0    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117594 BioGRID:112119 RPS11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117594 BioGRID:112136 RPS18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117594 BioGRID:112105 RPS4X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117594 BioGRID:112116 RPS8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117594 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117594 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:117594 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:117594 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117594 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Readthrough SENP3-EIF4A1

    Readthrough gene: SENP3-EIF4A1, Included gene: EIF4A1

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    MLL1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    sentrin-specific protease 3
    Names
    sentrin-specific protease 3
    SUMO-1-specific protease 3
    sentrin/SUMO-specific protease 3
    NP_056485.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015670.5 → NP_056485.2  sentrin-specific protease 3

      Status: VALIDATED

      Source sequence(s)
      BC048306, BF514106, BQ424754, BQ956948, CX165088
      UniProtKB/Swiss-Prot
      Q9H4L4
      Related
      ENSP00000314029, ENST00000321337
      Conserved Domains (1) summary
      pfam02902
      Location:400 – 572
      Blast Score: 378
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      7465309..7475287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      7359494..7369451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016876.10 (22409..32363) None
    genomic CH471108.2 EAW90170.1
      EAW90171.1
      EAW90172.1
    mRNA AF199459.1 AAL25652.1
    mRNA AK000923.1 None
    mRNA AL050283.1 CAB43384.2
    mRNA AL557688.3 None
    mRNA AL834294.1 CAD38967.1
    mRNA AY008763.1 AAG33252.1
    mRNA BC048306.1 AAH48306.1
    mRNA BC080658.1 AAH80658.1
    mRNA BF514106.1 None
    mRNA BQ424754.1 None
    mRNA BQ956948.1 None
    mRNA CX165088.1 None
    other-genetic AM392699.1 CAL37577.1
    other-genetic AM392708.1 CAL37586.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H4L4.2 GenPept UniProtKB/Swiss-Prot:Q9H4L4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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