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    EPC2 enhancer of polycomb homolog 2 (Drosophila) [ Homo sapiens (human) ]

    Gene ID: 26122, updated on 5-May-2013
    Official Symbol
    EPC2provided by HGNC
    Official Full Name
    enhancer of polycomb homolog 2 (Drosophila)provided by HGNC
    Primary source
    HGNC:24543
    See related
    Ensembl:ENSG00000135999; HPRD:13274; MIM:611000; Vega:OTTHUMG00000153739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EPC-LIKE
    Location :
    2q23.1
    Sequence :
    Chromosome: 2; NC_000002.11 (149402560..149545136)
    See EPC2 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene ADP-ribosylation factor-like 5A pseudogene Neighboring gene ribosomal protein S29 pseudogene 8 Neighboring gene ribosomal protein S20 pseudogene 13 Neighboring gene ubiquitin B pseudogene 3

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Intronic RNAs mediate EZH2 regulation of epigenetic targets. Guil S, et al. Nat Struct Mol Biol, 2012 Jun 3. PMID 22659877.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Kim S, et al. Neurology, 2011 Jan 4. PMID 21123754.
    4. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Kim J, et al. Cell, 2010 Oct 15. PMID 20946988.
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:117564 BioGRID:121004 DMAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117564 BioGRID:114265 EED    BioGRID  PubMed Protein-RNA 
    BioGRID:117564 BioGRID:108446 EZH2    BioGRID  PubMed Protein-RNA 
    BioGRID:117564 BioGRID:120041 ING3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117564 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117564 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117564 BioGRID:115001 MORF4L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117564 BioGRID:120548 MRGBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117564 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117564 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • DKFZp566F2124

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Piccolo NuA4 histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    enhancer of polycomb homolog 2
    Names
    enhancer of polycomb homolog 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015630.3 → NP_056445.3  enhancer of polycomb homolog 2

      Status: VALIDATED

      Source sequence(s)
      AK125789
      Consensus CDS
      CCDS46422.1
      UniProtKB/Swiss-Prot
      Q52LR7
      Related
      ENSP00000258484, OTTHUMP00000204350, ENST00000258484, OTTHUMT00000332278
      Conserved Domains (2) summary
      pfam06752
      Location:618 – 807
      Blast Score: 470
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:6 – 148
      Blast Score: 369
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p10 Primary Assembly

      Range
      149402560..149545136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      141400948..141543639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018913.1 Alternate CHM1_1.0

      Range
      148902459..149045086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01028002.1 (12022..13642) None
    genomic ABBA01028003.1 None
    genomic ABBA01028004.1 None
    genomic AC016763.8 AAY24275.1
    genomic AC017080.8 AAY14754.1
    genomic AMYH01011157.1 None
    genomic AMYH01011158.1 None
    genomic AMYH01011159.1 None
    genomic CH471058.2 EAX11547.1
      EAX11548.1
      EAX11549.1
    mRNA AF286904.1 AAK60500.1
    mRNA AK001433.1 BAA91688.1
    mRNA AK002010.1 BAA92032.1
    mRNA AK125789.1 BAG54249.1
    mRNA AL117558.1 CAB55993.1
    mRNA BC093818.1 AAH93818.1
    mRNA BC093820.1 AAH93820.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52LR7.2 GenPept UniProtKB/Swiss-Prot:Q52LR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

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