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EDRF1 erythroid differentiation regulatory factor 1 [ Homo sapiens (human) ]

Gene ID: 26098, updated on 26-May-2016
Official Symbol
EDRF1provided by HGNC
Official Full Name
erythroid differentiation regulatory factor 1provided by HGNC
Primary source
HGNC:HGNC:24640
See related
Ensembl:ENSG00000107938 HPRD:10694; Vega:OTTHUMG00000019233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf137
Summary
This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Orthologs
Location:
10q26.13
Exon count:
28
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (125719515..125764143)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (127408084..127452712)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene testis expressed 36 Neighboring gene aldolase, fructose-bisphosphate A pseudogene 2 Neighboring gene uncharacterized LOC283038 Neighboring gene uncharacterized LOC399821 Neighboring gene EDRF1 antisense RNA 1 Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene microRNA 4484

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC125705

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
erythroid differentiation-related factor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202438.1NP_001189367.1  erythroid differentiation-related factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001189367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL050102, AL158835, BC026172, BC107479
    Consensus CDS
    CCDS55733.1
    UniProtKB/Swiss-Prot
    Q3B7T1
    Related
    ENSP00000349244, OTTHUMP00000232253, ENST00000356792, OTTHUMT00000388539
  2. NM_015608.2NP_056423.2  erythroid differentiation-related factor 1 isoform 2

    See identical proteins and their annotated locations for NP_056423.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK091507, AL050102, BC026172
    Consensus CDS
    CCDS7646.1
    UniProtKB/Swiss-Prot
    Q3B7T1
    Related
    ENSP00000336727, OTTHUMP00000020703, ENST00000337623, OTTHUMT00000050921

RNA

  1. NR_110857.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL050102, AL158835, BC026172, BC105929
    Related
    ENST00000368815, OTTHUMT00000388540
  2. NR_110858.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL050102, AL158835, BC026172
    Related
    ENST00000419769, OTTHUMT00000388538
  3. NR_110859.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a different 3' structure and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL158835, BC028715
    Related
    ENST00000481600, OTTHUMT00000050923

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    125719515..125764143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539621.1XP_011537923.1  

  2. XM_005269687.2XP_005269744.1  

  3. XM_011539622.1XP_011537924.1  

RNA

  1. XR_945662.1 RNA Sequence

  2. XR_945663.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    127689817..127734444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030897.1: Suppressed sequence

    Description
    NM_030897.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.