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PTPN20 protein tyrosine phosphatase, non-receptor type 20 [ Homo sapiens (human) ]

Gene ID: 26095, updated on 13-Jun-2016
Official Symbol
PTPN20provided by HGNC
Official Full Name
protein tyrosine phosphatase, non-receptor type 20provided by HGNC
Primary source
HGNC:HGNC:23423
See related
Ensembl:ENSG00000204179 HPRD:10898; MIM:610630; MIM:610631; Vega:OTTHUMG00000018094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT126; PTPN20A; PTPN20B; bA42B19.1; bA142I17.1
Summary
The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Orthologs
Location:
10q11.22
Exon count:
18
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (46911134..47003834)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48737042..48827942, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 2 pseudogene Neighboring gene FERM and PDZ domain containing 2B, pseudogene Neighboring gene uncharacterized LOC105378291 Neighboring gene uncharacterized LOC101929216 Neighboring gene growth differentiation factor 10

Markers

Homology

Clone Names

  • KIAA0187, MGC142033, DKFZp566K0524, DKFZp781P23155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein phosphatase non-receptor type 20
Names
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20B
NP_001035816.1
NP_001035817.1
NP_001035818.1
NP_001035819.1
NP_001035820.1
NP_001035821.1
NP_001035822.1
NP_001035823.1
NP_001035824.1
NP_001307610.1
NP_001307611.1
NP_001307612.1
NP_001307613.1
NP_001307614.1
NP_001307615.1
NP_001307617.1
NP_001307618.1
NP_001307619.1
NP_001307620.1
NP_056420.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042357.4NP_001035816.1  tyrosine-protein phosphatase non-receptor type 20 isoform 1

    See identical proteins and their annotated locations for NP_001035816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL050040, AL358791, AY704146, BC036539, BC093750, BX648913
    Consensus CDS
    CCDS73110.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000363459, OTTHUMP00000217220, ENST00000374339, OTTHUMT00000358639
    Conserved Domains (2) summary
    smart00194
    Location:159411
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001042358.4NP_001035817.1  tyrosine-protein phosphatase non-receptor type 20 isoform 3

    See identical proteins and their annotated locations for NP_001035817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL358791, AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73105.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000424283, OTTHUMP00000217172, ENST00000511769, OTTHUMT00000358532
    Conserved Domains (2) summary
    smart00194
    Location:150402
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:176402
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001042359.3NP_001035818.1  tyrosine-protein phosphatase non-receptor type 20 isoform 4

    See identical proteins and their annotated locations for NP_001035818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and in the 5' coding region, compared to variant 1. It also lacks an in-frame segment of the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter and contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73107.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000425912, OTTHUMP00000217221, ENST00000513156, OTTHUMT00000358640
    Conserved Domains (2) summary
    smart00194
    Location:156260
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:142260
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_001042360.3NP_001035819.1  tyrosine-protein phosphatase non-receptor type 20 isoform 5

    See identical proteins and their annotated locations for NP_001035819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73109.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000379077, OTTHUMP00000217122, ENST00000395727, OTTHUMT00000358443
    Conserved Domains (2) summary
    cd00047
    Location:4219
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:4219
    Y_phosphatase; Protein-tyrosine phosphatase
  5. NM_001042361.4NP_001035820.1  tyrosine-protein phosphatase non-receptor type 20 isoform 6

    See identical proteins and their annotated locations for NP_001035820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 6) contains distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AL358791, AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73106.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000425362, OTTHUMP00000217128, ENST00000509774, OTTHUMT00000358451
    Conserved Domains (1) summary
    smart00194
    Location:150188
    PTPc; Protein tyrosine phosphatase, catalytic domain
  6. NM_001042362.3NP_001035821.1  tyrosine-protein phosphatase non-receptor type 20 isoform 7

    See identical proteins and their annotated locations for NP_001035821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 7) contains distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73108.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000427676, OTTHUMP00000217223, ENST00000503851, OTTHUMT00000358446
  7. NM_001042363.4NP_001035822.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

    See identical proteins and their annotated locations for NP_001035822.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11 and 12 encode the same isoform (8).
    Source sequence(s)
    AL050040, AL358791, AY704141, BC036539, BX648913
    Consensus CDS
    CCDS73114.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000363335, ENST00000374218
    Conserved Domains (2) summary
    smart00194
    Location:78330
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:104330
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  8. NM_001042364.4NP_001035823.1  tyrosine-protein phosphatase non-receptor type 20 isoform 9

    See identical proteins and their annotated locations for NP_001035823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. These differences cause translation initiation at a downstream AUG and a protein (isoform 9) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL050040, AL358791, BC036539, BX648913
    Consensus CDS
    CCDS73115.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000379075, ENST00000395725
    Conserved Domains (1) summary
    smart00194
    Location:78116
    PTPc; Protein tyrosine phosphatase, catalytic domain
  9. NM_001042365.3NP_001035824.1  tyrosine-protein phosphatase non-receptor type 20 isoform 10

    See identical proteins and their annotated locations for NP_001035824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. These differences cause translation initiation at a downstream AUG and a protein (isoform 10) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL050040, BC036539, BX648913
    Consensus CDS
    CCDS73116.1
    UniProtKB/TrEMBL
    Q4JDK3, Q9Y406
    Related
    ENSP00000363462, OTTHUMP00000276273, ENST00000374342, OTTHUMT00000358442
  10. NM_001320681.1NP_001307610.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11 and 12 encode the same isoform (8).
    Source sequence(s)
    AL050040, AL358791, AY704141, BC036539, BX648913
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000379071, OTTHUMP00000019514, ENST00000395721, OTTHUMT00000047815
    Conserved Domains (2) summary
    smart00194
    Location:78330
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:104330
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  11. NM_001320682.1NP_001307611.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15 encode the same isoform (11).
    Source sequence(s)
    BC036539, BC143394, BX648913, CR933668
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q5H9Q9
    Conserved Domains (1) summary
    cl21483
    Location:5183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  12. NM_001320683.1NP_001307612.1  tyrosine-protein phosphatase non-receptor type 20 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR and lacks two alternate exons in the coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Both variants 2 and 17 encode the same isoform (2).
    Source sequence(s)
    AL358791, AY704147, AY753191, BC036539, BC093750
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000425012, OTTHUMP00000217173, ENST00000509599, OTTHUMT00000358534
    Conserved Domains (1) summary
    smart00194
    Location:159197
    PTPc; Protein tyrosine phosphatase, catalytic domain
  13. NM_001320684.1NP_001307613.1  tyrosine-protein phosphatase non-receptor type 20 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR and lacks three alternate in-frame exons in the coding region compared to variant 1. The encoded isoform (13) is shorter than isoform 1.
    Source sequence(s)
    AY704148, AY753191, BC036539, BC143394
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000420995, OTTHUMP00000217126, ENST00000502705, OTTHUMT00000358449
    Conserved Domains (1) summary
    cl21483
    Location:158197
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  14. NM_001320685.1NP_001307614.1  tyrosine-protein phosphatase non-receptor type 20 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR and lacks one alternate exon in the 5' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (14) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL358791, AY704150, AY753191, BC036539, BX005072
    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:131383
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:157383
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  15. NM_001320686.1NP_001307615.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11 and 12 encode the same isoform (8).
    Source sequence(s)
    AL358791, AY704152, AY753191, BC036539
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000426355, OTTHUMP00000217127, ENST00000505814, OTTHUMT00000358450
    Conserved Domains (2) summary
    smart00194
    Location:78330
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:104330
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  16. NM_001320688.1NP_001307617.1  tyrosine-protein phosphatase non-receptor type 20 isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR and has multiple coding region differences compared to variant 1. The encoded isoform (15) is shorter than isoform 1.
    Source sequence(s)
    AY704153, AY753191, BC036539
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000422839, OTTHUMP00000217125, ENST00000513266, OTTHUMT00000358448
    Conserved Domains (2) summary
    smart00194
    Location:84188
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:70188
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  17. NM_001320689.1NP_001307618.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15 encode the same isoform (11).
    Source sequence(s)
    AY704156, AY753191, BC036539
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q4JDK3
    Conserved Domains (1) summary
    cl21483
    Location:5183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  18. NM_001320690.1NP_001307619.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15 encode the same isoform (11).
    Source sequence(s)
    AY704157, AY753191, BC036539
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q4JDK3
    Conserved Domains (1) summary
    cl21483
    Location:5183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  19. NM_001320691.1NP_001307620.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start site compared to variant 1. The encoded isoform (12) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AY704158, AY753191, BC036539
    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:1170
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  20. NM_015605.8NP_056420.3  tyrosine-protein phosphatase non-receptor type 20 isoform 2

    See identical proteins and their annotated locations for NP_056420.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate exons in the coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Both variants 2 and 17 encode the same isoform (2).
    Source sequence(s)
    AL050040, AL358791, AY704146, BC036539, BC093750, BX648913
    Consensus CDS
    CCDS73111.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000363466, OTTHUMP00000019515, ENST00000374346, OTTHUMT00000047816
    Conserved Domains (1) summary
    smart00194
    Location:159197
    PTPc; Protein tyrosine phosphatase, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

    Range
    46911134..47003834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016050.1XP_016871539.1  

  2. XM_017016061.1XP_016871550.1  

  3. XM_017016064.1XP_016871553.1  

    Related
    ENSP00000379072, OTTHUMP00000276274, ENST00000395722, OTTHUMT00000358444
  4. XM_017016044.1XP_016871533.1  

  5. XM_017016054.1XP_016871543.1  

  6. XM_017016057.1XP_016871546.1  

  7. XM_017016051.1XP_016871540.1  

  8. XM_017016048.1XP_016871537.1  

  9. XM_017016043.1XP_016871532.1  

  10. XM_017016063.1XP_016871552.1  

    Related
    ENSP00000479990, OTTHUMP00000276277, ENST00000513756, OTTHUMT00000358538
  11. XM_017016042.1XP_016871531.1  

  12. XM_017016046.1XP_016871535.1  

  13. XM_017016055.1XP_016871544.1  

  14. XM_017016053.1XP_016871542.1  

  15. XM_017016060.1XP_016871549.1  

    Related
    ENSP00000421404, OTTHUMP00000217174, ENST00000502254, OTTHUMT00000358535
  16. XM_017016065.1XP_016871554.1  

    Related
    ENSP00000480504, OTTHUMP00000276276, ENST00000508715, OTTHUMT00000358540
  17. XM_017016047.1XP_016871536.1  

  18. XM_017016052.1XP_016871541.1  

  19. XM_011539610.2XP_011537912.1  

    See identical proteins and their annotated locations for XP_011537912.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:78330
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:104330
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  20. XM_017016049.1XP_016871538.1  

  21. XM_017016058.1XP_016871547.1  

  22. XM_011539605.2XP_011537907.1  

    See identical proteins and their annotated locations for XP_011537907.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:159411
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  23. XM_017016062.1XP_016871551.1  

  24. XM_017016056.1XP_016871545.1  

  25. XM_017016059.1XP_016871548.1  

    Related
    ENSP00000423819, OTTHUMP00000217123, ENST00000509900, OTTHUMT00000358445
  26. XM_011539607.2XP_011537909.1  

    See identical proteins and their annotated locations for XP_011537909.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:159411
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  27. XM_011539606.2XP_011537908.1  

    See identical proteins and their annotated locations for XP_011537908.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:159411
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  28. XM_011539611.2XP_011537913.1  

    Conserved Domains (2) summary
    cd00047
    Location:108323
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:108323
    Y_phosphatase; Protein-tyrosine phosphatase
  29. XM_017016045.1XP_016871534.1  

RNA

  1. XR_001747082.1 RNA Sequence

  2. XR_001747083.1 RNA Sequence

  3. XR_001747084.1 RNA Sequence

    Related
    ENST00000437863, OTTHUMT00000358539
  4. XR_001747085.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    48901986..49614050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042387.1: Suppressed sequence

    Description
    NM_001042387.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  2. NM_001042389.1: Suppressed sequence

    Description
    NM_001042389.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  3. NM_001042390.1: Suppressed sequence

    Description
    NM_001042390.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  4. NM_001042391.1: Suppressed sequence

    Description
    NM_001042391.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  5. NM_001042392.1: Suppressed sequence

    Description
    NM_001042392.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  6. NM_001042393.1: Suppressed sequence

    Description
    NM_001042393.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  7. NM_001042394.1: Suppressed sequence

    Description
    NM_001042394.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  8. NM_001042395.1: Suppressed sequence

    Description
    NM_001042395.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  9. NM_001042396.1: Suppressed sequence

    Description
    NM_001042396.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  10. NM_001042397.1: Suppressed sequence

    Description
    NM_001042397.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.