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PTPN20B protein tyrosine phosphatase, non-receptor type 20B [ Homo sapiens (human) ]

Gene ID: 26095, updated on 7-Aug-2014
Official Symbol
PTPN20Bprovided by HGNC
Official Full Name
protein tyrosine phosphatase, non-receptor type 20Bprovided by HGNC
Primary source
HGNC:23423
Locus tag
RP11-142I17.1
See related
Ensembl:ENSG00000183675; Ensembl:ENSG00000204179; HPRD:10898; MIM:610630; MIM:610631; Vega:OTTHUMG00000018094; Vega:OTTHUMG00000018151
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT126; PTPN20A; hPTPN20; bA42B19.1; bA142I17.1
Summary
The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
See PTPN20B in Epigenomics, MapViewer
Location:
10q11.22
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (46911420..47002320)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48737042..48827942, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 2 pseudogene Neighboring gene FERM and PDZ domain containing 2B, pseudogene Neighboring gene uncharacterized LOC101929216 Neighboring gene growth differentiation factor 10

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0187, MGC142033, DKFZp566K0524, DKFZp781P23155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein phosphatase non-receptor type 20
Names
tyrosine-protein phosphatase non-receptor type 20
cancer/testis antigen 126
protein tyrosine phosphatase, non-receptor type 20A
NP_001035816.1
NP_001035817.1
NP_001035818.1
NP_001035819.1
NP_001035820.1
NP_001035821.1
NP_001035822.1
NP_001035823.1
NP_001035824.1
NP_001035846.1
NP_001035848.1
NP_001035849.1
NP_001035850.1
NP_001035852.1
NP_001035853.1
NP_001035854.1
NP_056420.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042357.3NP_001035816.1  tyrosine-protein phosphatase non-receptor type 20 isoform 1

    See proteins identical to NP_001035816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AL358791, AY704146, BC036539, BC093750
    Consensus CDS
    CCDS73110.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000379020, ENST00000395660
    Conserved Domains (2) summary
    smart00194
    Location:159411
    Blast Score: 845
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    Blast Score: 818
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001042358.3NP_001035817.1  tyrosine-protein phosphatase non-receptor type 20 isoform 3

    See proteins identical to NP_001035817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL358791, AY704141, BC036539
    Consensus CDS
    CCDS73105.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:150402
    Blast Score: 842
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:176402
    Blast Score: 815
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001042359.2NP_001035818.1  tyrosine-protein phosphatase non-receptor type 20 isoform 4

    See proteins identical to NP_001035818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and in the 5' coding region, compared to variant 1. It also lacks an in-frame segment of the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter and contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AY704141, BC036539
    Consensus CDS
    CCDS73107.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000363352, ENST00000374235
    Conserved Domains (2) summary
    smart00194
    Location:156260
    Blast Score: 398
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:142260
    Blast Score: 407
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_001042360.2NP_001035819.1  tyrosine-protein phosphatase non-receptor type 20 isoform 5

    See proteins identical to NP_001035819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AY704141, BC036539
    Consensus CDS
    CCDS73109.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    cd00047
    Location:4219
    Blast Score: 721
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:4219
    Blast Score: 695
    Y_phosphatase; Protein-tyrosine phosphatase
  5. NM_001042361.3NP_001035820.1  tyrosine-protein phosphatase non-receptor type 20 isoform 6

    See proteins identical to NP_001035820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 6) contains distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AL358791, AY704141, BC036539
    Consensus CDS
    CCDS73106.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (1) summary
    smart00194
    Location:150188
    Blast Score: 101
    PTPc; Protein tyrosine phosphatase, catalytic domain
  6. NM_001042362.2NP_001035821.1  tyrosine-protein phosphatase non-receptor type 20 isoform 7

    See proteins identical to NP_001035821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 7) contains distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AY704141, BC036539
    Consensus CDS
    CCDS73108.1
    UniProtKB/Swiss-Prot
    Q4JDL3
  7. NM_001042363.3NP_001035822.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

    See proteins identical to NP_001035822.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 8) contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL050040, AL358791, AY704141, BC036539
    Consensus CDS
    CCDS73114.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000379027, ENST00000395668
    Conserved Domains (2) summary
    smart00194
    Location:78330
    Blast Score: 837
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:104330
    Blast Score: 808
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  8. NM_001042364.3NP_001035823.1  tyrosine-protein phosphatase non-receptor type 20 isoform 9

    See proteins identical to NP_001035823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. These differences cause translation initiation at a downstream AUG and a protein (isoform 9) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL050040, AL358791, BC036539
    Consensus CDS
    CCDS73115.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000379022, ENST00000395662
    Conserved Domains (1) summary
    smart00194
    Location:78116
    Blast Score: 101
    PTPc; Protein tyrosine phosphatase, catalytic domain
  9. NM_001042365.2NP_001035824.1  tyrosine-protein phosphatase non-receptor type 20 isoform 10

    See proteins identical to NP_001035824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. These differences cause translation initiation at a downstream AUG and a protein (isoform 10) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL050040, BC036539
    Consensus CDS
    CCDS73116.1
    UniProtKB/TrEMBL
    Q4JDK3
    UniProtKB/TrEMBL
    Q9Y406
  10. NM_015605.7NP_056420.3  tyrosine-protein phosphatase non-receptor type 20 isoform 2

    See proteins identical to NP_056420.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a longer 5' UTR and lacks a segment of the coding region, compared to variant 1. The resulting protein (isoform 2) contains a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL050040, AL358791, AY704146, BC036539, BC093750
    Consensus CDS
    CCDS73111.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000363357, OTTHUMP00000019541, ENST00000374240, OTTHUMT00000047896
    Conserved Domains (1) summary
    smart00194
    Location:159197
    Blast Score: 101
    PTPc; Protein tyrosine phosphatase, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    46911420..47002320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005277652.1XP_005277709.1  

    See proteins identical to XP_005277709.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:78330
    Blast Score: 837
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:104330
    Blast Score: 808
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_005270315.1XP_005270372.1  

    See proteins identical to XP_005270372.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000331832, OTTHUMP00000019540, ENST00000331650, OTTHUMT00000047895
    Conserved Domains (2) summary
    smart00194
    Location:78330
    Blast Score: 837
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:104330
    Blast Score: 808
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_006717756.1XP_006717819.1  

    See proteins identical to XP_006717819.1

    UniProtKB/TrEMBL
    Q4JDK3
  4. XM_006717754.1XP_006717817.1  

    See proteins identical to XP_006717817.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (1) summary
    cd00047
    Location:158197
    Blast Score: 153
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. XM_006717755.1XP_006717818.1  

    See proteins identical to XP_006717818.1

    UniProtKB/Swiss-Prot
    Q4JDL3

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    43492180..43529513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. AC_000142.1 

    Range
    43590730..43596824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    48901986..48992848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NC_018921.2 

    Range
    49595093..49601239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042387.1: Suppressed sequence

    Description
    NM_001042387.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  2. NM_001042389.1: Suppressed sequence

    Description
    NM_001042389.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  3. NM_001042390.1: Suppressed sequence

    Description
    NM_001042390.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  4. NM_001042391.1: Suppressed sequence

    Description
    NM_001042391.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  5. NM_001042392.1: Suppressed sequence

    Description
    NM_001042392.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  6. NM_001042393.1: Suppressed sequence

    Description
    NM_001042393.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  7. NM_001042394.1: Suppressed sequence

    Description
    NM_001042394.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  8. NM_001042395.1: Suppressed sequence

    Description
    NM_001042395.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  9. NM_001042396.1: Suppressed sequence

    Description
    NM_001042396.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  10. NM_001042397.1: Suppressed sequence

    Description
    NM_001042397.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.