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DECR2 2,4-dienoyl-CoA reductase 2, peroxisomal [ Homo sapiens (human) ]

Gene ID: 26063, updated on 26-May-2016
Official Symbol
DECR2provided by HGNC
Official Full Name
2,4-dienoyl-CoA reductase 2, peroxisomalprovided by HGNC
Primary source
HGNC:HGNC:2754
See related
Ensembl:ENSG00000242612 HPRD:16789; MIM:615839; Vega:OTTHUMG00000047846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDCR; SDR17C1
Orthologs
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (401858..412487)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (451858..462487)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100134368 Neighboring gene uncharacterized LOC105371036 Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene uncharacterized LOC105371037 Neighboring gene RAB11 family interacting protein 3

  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: NME4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
trans-2-enoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
trans-2-enoyl-CoA reductase (NADPH) activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular lipid metabolic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
unsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
peroxisomal membrane TAS
Traceable Author Statement
more info
 
Preferred Names
peroxisomal 2,4-dienoyl-CoA reductase
Names
2,4-dienoyl CoA reductase 2, peroxisomal
2,4-dienoyl-CoA reductase 2
short chain dehydrogenase/reductase family 17C member 1
short chain dehydrogenase/reductase family 17C, member 1
NP_065715.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020664.3NP_065715.1  peroxisomal 2,4-dienoyl-CoA reductase

    See identical proteins and their annotated locations for NP_065715.1

    Status: VALIDATED

    Source sequence(s)
    AK055839, BC010740, BC030226
    Consensus CDS
    CCDS10409.1
    UniProtKB/Swiss-Prot
    Q9NUI1
    Related
    ENSP00000219481, OTTHUMP00000045513, ENST00000219481, OTTHUMT00000109069
    Conserved Domains (2) summary
    cd05369
    Location:26273
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK07576
    Location:29273
    PRK07576; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    401858..412487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187610.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    1004..11633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    451798..462431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)