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ANKRD17 ankyrin repeat domain 17 [ Homo sapiens (human) ]

Gene ID: 26057, updated on 8-May-2016
Official Symbol
ANKRD17provided by HGNC
Official Full Name
ankyrin repeat domain 17provided by HGNC
Primary source
HGNC:HGNC:23575
See related
Ensembl:ENSG00000132466 HPRD:10648; MIM:615929; Vega:OTTHUMG00000160826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTAR; MASK2; NY-BR-16
Summary
The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Orthologs
Location:
4q13.3
Exon count:
37
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (73074785..73259142, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (73940502..74124858, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6atac small nuclear 5, pseudogene Neighboring gene COX18 cytochrome c oxidase assembly factor Neighboring gene high mobility group AT-hook 1 pseudogene 2 Neighboring gene uncharacterized LOC102724832 Neighboring gene albumin Neighboring gene alpha fetoprotein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of ankyrin repeat domain 17 (ANKRD17) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with ankyrin repeat domain 17 (ANKRD17) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22206, KIAA0697

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blood vessel maturation IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MDA-5 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of RIG-I signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ankyrin repeat domain-containing protein 17
Names
gene trap ankyrin repeat protein
serologically defined breast cancer antigen NY-BR-16

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286771.2NP_001273700.1  ankyrin repeat domain-containing protein 17 isoform c

    See identical proteins and their annotated locations for NP_001273700.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant a. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AB014597, AI016364, BC004173, BM755557, BM971664, BU608983, BX648035, CA310544, DC335632
    Consensus CDS
    CCDS68721.1
    UniProtKB/Swiss-Prot
    O75179
    Related
    ENSP00000427151, OTTHUMP00000219061, ENST00000509867, OTTHUMT00000362477
    Conserved Domains (7) summary
    COG0195
    Location:16071654
    NusA; Transcription antitermination factor NusA, contains S1 and KH domains [Transcription]
    cd00105
    Location:16141676
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:283407
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:9691001
    Ank; Ankyrin repeat
    pfam03938
    Location:681780
    OmpH; Outer membrane protein (OmpH-like)
    pfam12796
    Location:192281
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:9701023
    Ank_4; Ankyrin repeats (many copies)
  2. NM_015574.1NP_056389.1  ankyrin repeat domain-containing protein 17 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region codon compared to variant a. The encoded isoform (d) is one amino acid shorter than isoform a.
    Source sequence(s)
    AB014597, AF308285, AI016364, AK307581, BM755557, BM971664, CB164101
    UniProtKB/Swiss-Prot
    O75179
    Conserved Domains (7) summary
    COG0195
    Location:17191766
    NusA; Transcription antitermination factor NusA, contains S1 and KH domains [Transcription]
    cd00105
    Location:17261788
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:396520
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:10811113
    Ank; Ankyrin repeat
    pfam03938
    Location:794893
    OmpH; Outer membrane protein (OmpH-like)
    pfam12796
    Location:305394
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10821135
    Ank_4; Ankyrin repeats (many copies)
  3. NM_032217.4NP_115593.3  ankyrin repeat domain-containing protein 17 isoform a

    See identical proteins and their annotated locations for NP_115593.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB014597, AF308285, AI016364, AI680274, AK307581, BC004173, BM755557, BM971664, BX648035, CD690889
    Consensus CDS
    CCDS34004.1
    UniProtKB/Swiss-Prot
    O75179
    Related
    ENSP00000351416, OTTHUMP00000219059, ENST00000358602, OTTHUMT00000362475
    Conserved Domains (7) summary
    COG0195
    Location:17201767
    NusA; Transcription antitermination factor NusA, contains S1 and KH domains [Transcription]
    cd00105
    Location:17271789
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:396520
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:10821114
    Ank; Ankyrin repeat
    pfam03938
    Location:794893
    OmpH; Outer membrane protein (OmpH-like)
    pfam12796
    Location:305394
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10831136
    Ank_4; Ankyrin repeats (many copies)
  4. NM_198889.2NP_942592.1  ankyrin repeat domain-containing protein 17 isoform b

    See identical proteins and their annotated locations for NP_942592.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter than isoform a.
    Source sequence(s)
    AB014597, AF308285, AI016364, AI680274, AK307581, BC004173, BC009043, BM755557, BM971664, CD690889
    Consensus CDS
    CCDS34003.1
    UniProtKB/Swiss-Prot
    O75179
    Related
    ENSP00000332265, OTTHUMP00000219060, ENST00000330838, OTTHUMT00000362476
    Conserved Domains (6) summary
    COG0195
    Location:14691516
    NusA; Transcription antitermination factor NusA, contains S1 and KH domains [Transcription]
    cd00105
    Location:14761538
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:396520
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:10001032
    Ank; Ankyrin repeat
    pfam12796
    Location:305394
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:832885
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    73074785..73259142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265671.3XP_005265728.1  

    Conserved Domains (6) summary
    COG0195
    Location:14681515
    NusA; Transcription antitermination factor NusA, contains S1 and KH domains [Transcription]
    cd00105
    Location:14751537
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:396520
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:9991031
    Ank; Ankyrin repeat
    pfam12796
    Location:305394
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:831884
    Ank_4; Ankyrin repeats (many copies)
  2. XM_005265667.3XP_005265724.1  

    Related
    ENSP00000453434, OTTHUMP00000248613, ENST00000558247, OTTHUMT00000418945
    Conserved Domains (7) summary
    COG0195
    Location:17191766
    NusA; Transcription antitermination factor NusA, contains S1 and KH domains [Transcription]
    cd00105
    Location:17261788
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:396520
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:10811113
    Ank; Ankyrin repeat
    pfam03938
    Location:794893
    OmpH; Outer membrane protein (OmpH-like)
    pfam12796
    Location:305394
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10821135
    Ank_4; Ankyrin repeats (many copies)
  3. XM_005265672.3XP_005265729.1  

    Conserved Domains (5) summary
    cd00204
    Location:396520
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:10821114
    Ank; Ankyrin repeat
    pfam03938
    Location:794893
    OmpH; Outer membrane protein (OmpH-like)
    pfam12796
    Location:305394
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10831136
    Ank_4; Ankyrin repeats (many copies)
  4. XM_005265673.2XP_005265730.1  

    Conserved Domains (5) summary
    cd00204
    Location:396520
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:10821114
    Ank; Ankyrin repeat
    pfam03938
    Location:794893
    OmpH; Outer membrane protein (OmpH-like)
    pfam12796
    Location:305394
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10831136
    Ank_4; Ankyrin repeats (many copies)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    73976362..74160315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)