These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_001142782.1 → NP_001136254.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
- Source sequence(s)
-
AA992863, AB046854, AK311589, BC130409
- Consensus CDS
-
CCDS44196.1
- UniProtKB/Swiss-Prot
-
Q5TCQ9
- Related
- ENSP00000304604, OTTHUMP00000013457, ENST00000307546, OTTHUMT00000032429
- Conserved Domains (4) summary
-
- cd00992
Location:1022 – 1100
Blast Score: 209
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd00201
Location:296 – 325
Blast Score: 120
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- pfam09726
Location:1121 – 1435
Blast Score: 97
- Macoilin; Transmembrane protein
- cl09099
Location:123 – 223
Blast Score: 200
- P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
-
NM_152900.2 → NP_690864.2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) uses an alternate splice site at the 5' end of the last coding exon, compared to variant 1, that results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AL133517, BC130409
- Consensus CDS
-
CCDS860.1
- UniProtKB/Swiss-Prot
-
Q5TCQ9
- Related
- ENSP00000358624, OTTHUMP00000013454, ENST00000369611, OTTHUMT00000032426
- Conserved Domains (3) summary
-
- cd00992
Location:1022 – 1100
Blast Score: 208
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd00201
Location:296 – 325
Blast Score: 121
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl09099
Location:123 – 223
Blast Score: 201
- P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000001.10 Reference GRCh37.p5 Primary Assembly
- Range
- 113933475..114228545
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000133.1 Alternate HuRef
- Range
- 111790744..112086122
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_020965.2: Suppressed sequence
- Description
- NM_020965.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.