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CYP4X1 cytochrome P450 family 4 subfamily X member 1 [ Homo sapiens (human) ]

Gene ID: 260293, updated on 8-May-2016
Official Symbol
CYP4X1provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily X member 1provided by HGNC
Primary source
HGNC:HGNC:20244
See related
Ensembl:ENSG00000186377 HPRD:13110; MIM:614999; Vega:OTTHUMG00000008017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPIVX1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Orthologs
Location:
1p33; 1
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (46961364..47050751)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47427036..47516423)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily Z member 2, pseudogene Neighboring gene tubulin alpha 1c pseudogene Neighboring gene cytochrome P450 family 4 subfamily A member 11 Neighboring gene cytochrome P450 family 4 subfamily A member 27, pseudogene Neighboring gene uncharacterized LOC105378700 Neighboring gene tubulin alpha 1c pseudogene Neighboring gene cytochrome P450 family 4 subfamily Z member 1 Neighboring gene cytochrome P450 family 4 subfamily A member 22

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC40051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytochrome P450 4X1
Names
cytochrome P450, family 4, subfamily X, polypeptide 1
NP_828847.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007966.2 RefSeqGene

    Range
    67205..94388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320289.1NP_001307218.1  cytochrome P450 4X1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI923200, AK091806, AK131355
    UniProtKB/Swiss-Prot
    Q8N118
    Conserved Domains (1) summary
    pfam00067
    Location:58500
    p450; Cytochrome P450
  2. NM_001320290.1NP_001307219.1  cytochrome P450 4X1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstrean in-frame start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AI923200, AK091806
    UniProtKB/Swiss-Prot
    Q8N118
    Conserved Domains (1) summary
    pfam00067
    Location:9436
    p450; Cytochrome P450
  3. NM_178033.1NP_828847.1  cytochrome P450 4X1 isoform 1

    See identical proteins and their annotated locations for NP_828847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC028102
    Consensus CDS
    CCDS544.1
    UniProtKB/Swiss-Prot
    Q8N118
    Related
    ENSP00000360968, OTTHUMP00000009712, ENST00000371901, OTTHUMT00000022017
    Conserved Domains (1) summary
    pfam00067
    Location:47501
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    46961364..47050751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541206.1XP_011539508.1  

    Conserved Domains (1) summary
    pfam00067
    Location:58500
    p450; Cytochrome P450
  2. XM_011541207.1XP_011539509.1  

    Conserved Domains (1) summary
    pfam00067
    Location:9436
    p450; Cytochrome P450

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    47606010..47633192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)