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NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor [ Homo sapiens (human) ]

Gene ID: 26012, updated on 8-May-2016
Official Symbol
NSMFprovided by HGNC
Official Full Name
NMDA receptor synaptonuclear signaling and neuronal migration factorprovided by HGNC
Primary source
HGNC:HGNC:29843
See related
Ensembl:ENSG00000165802 HPRD:10485; MIM:608137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH9; NELF
Summary
The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Orthologs
Location:
9q34.3
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (137447570..137459357, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140342022..140353808, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene exonuclease 3'-5' domain containing 3 Neighboring gene NADPH oxidase activator 1 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 8 Neighboring gene microRNA 7114 Neighboring gene patatin like phospholipase domain containing 7 Neighboring gene mitochondrial ribosomal protein L41

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC125369

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to electrical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to gonadotropin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cortical cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear euchromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
NMDA receptor synaptonuclear signaling and neuronal migration factor
Names
nasal embryonic LHRH factor
nasal embryonic luteinizing hormone-releasing hormone factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021362.1 RefSeqGene

    Range
    5001..16765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130969.1NP_001124441.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform a

    See identical proteins and their annotated locations for NP_001124441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AW072125, AY255128, BM023184, CN306732
    Consensus CDS
    CCDS48069.1
    UniProtKB/Swiss-Prot
    Q6X4W1
    Related
    ENSP00000360530, ENST00000371475
  2. NM_001130970.1NP_001124442.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform c

    See identical proteins and their annotated locations for NP_001124442.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AW072125, AY255130, BM023184, CN306732
    Consensus CDS
    CCDS48068.1
    UniProtKB/Swiss-Prot
    Q6X4W1
    Related
    ENSP00000412007, ENST00000437259
  3. NM_001130971.1NP_001124443.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform d

    See identical proteins and their annotated locations for NP_001124443.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AW072125, AY255128, BC110498, BM023184, CN306732
    Consensus CDS
    CCDS48067.1
    UniProtKB/Swiss-Prot
    Q6X4W1
    Related
    ENSP00000360529, ENST00000371474
  4. NM_001178064.1NP_001171535.1  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform e

    See identical proteins and their annotated locations for NP_001171535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AW072125, AY255131, BM023184, CN306732
    Consensus CDS
    CCDS55357.1
    UniProtKB/Swiss-Prot
    Q6X4W1
    Related
    ENSP00000360528, ENST00000371473
  5. NM_015537.4NP_056352.3  NMDA receptor synaptonuclear signaling and neuronal migration factor isoform b

    See identical proteins and their annotated locations for NP_056352.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AW072125, AY255128, BC072412, BM023184, CN306732
    Consensus CDS
    CCDS7044.1
    UniProtKB/Swiss-Prot
    Q6X4W1
    Related
    ENSP00000265663, ENST00000265663

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    137447570..137459357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266062.3XP_005266119.1  

  2. XM_005266061.3XP_005266118.1  

    See identical proteins and their annotated locations for XP_005266118.1

  3. XM_011518496.1XP_011516798.1  

  4. XM_011518497.1XP_011516799.1  

    See identical proteins and their annotated locations for XP_011516799.1

    UniProtKB/TrEMBL
    A8K7L5
    Related
    ENSP00000342966, OTTHUMP00000022698, ENST00000339554, OTTHUMT00000055330

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    140490446..140501310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)