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TENM4 teneurin transmembrane protein 4 [ Homo sapiens (human) ]

Gene ID: 26011, updated on 8-May-2016
Official Symbol
TENM4provided by HGNC
Official Full Name
teneurin transmembrane protein 4provided by HGNC
Primary source
HGNC:HGNC:29945
See related
Ensembl:ENSG00000149256 MIM:610084; Vega:OTTHUMG00000166770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Doc4; ETM5; ODZ4; TNM4; Ten-M4
Orthologs
Location:
11q14.1
Exon count:
40
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (78653283..79440989, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (78364328..79152014, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369403 Neighboring gene uncharacterized LOC101928896 Neighboring gene asparaginyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene uncharacterized LOC105369404 Neighboring gene microRNA 708 Neighboring gene microRNA 5579 Neighboring gene uncharacterized LOC105369405 Neighboring gene origin recognition complex subunit 3 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
NHGRI GWA Catalog
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
NHGRI GWA Catalog
Genome-wide association study of retinopathy in individuals without diabetes.
NHGRI GWA Catalog
Genome-wide association study reveals two new risk loci for bipolar disorder.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ99165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cardiac cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
central nervous system myelin formation ISS
Inferred from Sequence or Structural Similarity
more info
 
gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
neuron development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
self proteolysis IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
teneurin-4
Names
odd Oz/ten-m homolog 4
odz, odd Oz/ten-m homolog 4
protein Odd Oz/ten-m homolog 4
ten-4
tenascin-M4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098816.2NP_001092286.2  teneurin-4

    See identical proteins and their annotated locations for NP_001092286.2

    Status: VALIDATED

    Source sequence(s)
    AB037723, AP001838, AP002515, AP002768, AP002957, BX640737, DR000247
    Consensus CDS
    CCDS44688.1
    UniProtKB/Swiss-Prot
    Q6N022
    Related
    ENSP00000278550, OTTHUMP00000234170, ENST00000278550, OTTHUMT00000391406
    Conserved Domains (9) summary
    COG3209
    Location:16822474
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:635658
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01500
    Location:627775
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26842762
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:12321271
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16761716
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23822461
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12221563
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    78653283..79440989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544929.1XP_011543231.1  

    Conserved Domains (9) summary
    COG3209
    Location:16652457
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:627650
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01500
    Location:619767
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:35332
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26672745
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:12151254
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16591699
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23652444
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12051546
    NHL; NHL repeat unit of beta-propeller proteins
  2. XM_011544927.1XP_011543229.1  

    Conserved Domains (9) summary
    COG3209
    Location:16912483
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:660683
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01500
    Location:652800
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:35365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26932771
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:12481274
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16851725
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23912470
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12381572
    NHL; NHL repeat unit of beta-propeller proteins
  3. XM_011544924.1XP_011543226.1  

    See identical proteins and their annotated locations for XP_011543226.1

    Conserved Domains (9) summary
    COG3209
    Location:16982490
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:660683
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01500
    Location:652800
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:35365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27002778
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:12481287
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16921732
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23982477
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12381579
    NHL; NHL repeat unit of beta-propeller proteins
  4. XM_011544928.1XP_011543230.1  

    Conserved Domains (9) summary
    COG3209
    Location:16732465
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:635658
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01500
    Location:627775
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:10340
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26752753
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:12231262
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16671707
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23732452
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12131554
    NHL; NHL repeat unit of beta-propeller proteins
  5. XM_011544930.1XP_011543232.1  

    Conserved Domains (9) summary
    COG3209
    Location:16302422
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:592615
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01500
    Location:584732
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:53297
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:26322710
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:11801219
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16241664
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23302409
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:11701511
    NHL; NHL repeat unit of beta-propeller proteins
  6. XM_011544925.1XP_011543227.1  

    See identical proteins and their annotated locations for XP_011543227.1

    Conserved Domains (9) summary
    COG3209
    Location:16982490
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:660683
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01500
    Location:652800
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:35365
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:27002778
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:12481287
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16921732
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23982477
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:12381579
    NHL; NHL repeat unit of beta-propeller proteins
  7. XM_011544931.1XP_011543233.1  

    Conserved Domains (8) summary
    COG3209
    Location:13112103
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:273296
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01500
    Location:265413
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam15636
    Location:23132391
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:861900
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:13051345
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:20112090
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:8511192
    NHL; NHL repeat unit of beta-propeller proteins
  8. XM_011544932.1XP_011543234.1  

    Conserved Domains (6) summary
    COG3209
    Location:7691465
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    pfam15636
    Location:18511929
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:399438
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:843883
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:15491628
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:389730
    NHL; NHL repeat unit of beta-propeller proteins
  9. XM_011544933.1XP_011543235.1  

    Conserved Domains (6) summary
    COG3209
    Location:7501446
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    pfam15636
    Location:18321910
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:380419
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:824864
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:15301609
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:370711
    NHL; NHL repeat unit of beta-propeller proteins
  10. XM_011544934.1XP_011543236.1  

    Conserved Domains (6) summary
    COG3209
    Location:235931
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    pfam15636
    Location:13171395
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cd05819
    Location:3985
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:309349
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:10151094
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:2196
    NHL; NHL repeat unit of beta-propeller proteins

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    78247331..79034525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)