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SEC31B SEC31 homolog B, COPII coat complex component [ Homo sapiens (human) ]

Gene ID: 25956, updated on 26-May-2016
Official Symbol
SEC31Bprovided by HGNC
Official Full Name
SEC31 homolog B, COPII coat complex componentprovided by HGNC
Primary source
HGNC:HGNC:23197
See related
Ensembl:ENSG00000075826 HPRD:15315; MIM:610258; Vega:OTTHUMG00000019342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC31L2; SEC31B-1
Summary
This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008]
Orthologs
Location:
10q24.31
Exon count:
26
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (100486646..100519838, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102246397..102279711, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene oligodendrocyte maturation-associated long intergenic non-coding RNA Neighboring gene uncharacterized LOC105378452 Neighboring gene Wnt family member 8B Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 Neighboring gene hypoxia inducible factor 1 alpha subunit inhibitor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog
  • COPII complex, organism-specific biosystem (from KEGG)
    COPII complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
  • COPII complex, conserved biosystem (from KEGG)
    COPII complex, conserved biosystemStructural complex; Genetic information processing; Protein processing
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • SREBP signalling, organism-specific biosystem (from WikiPathways)
    SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: NDUFB8

Homology

Clone Names

  • DKFZp434M183

Gene Ontology Provided by GOA

Process Evidence Code Pubs
protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein transport protein Sec31B
Names
SEC31 homolog B
SEC31 homolog B, COPII coating complex component
SEC31-like 2
SEC31-like protein 2
SEC31-related protein B
secretory pathway component Sec31B-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015490.3NP_056305.1  protein transport protein Sec31B

    See identical proteins and their annotated locations for NP_056305.1

    Status: REVIEWED

    Source sequence(s)
    AF274863, BC034946, BM719543
    Consensus CDS
    CCDS7495.1
    UniProtKB/Swiss-Prot
    Q9NQW1
    Related
    ENSP00000359370, OTTHUMP00000020817, ENST00000370345, OTTHUMT00000051198
    Conserved Domains (3) summary
    COG2319
    Location:36356
    WD40; WD40 repeat [General function prediction only]
    cl14807
    Location:561691
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl02567
    Location:13332
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    100486646..100519838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    102531040..102564247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198138.1: Suppressed sequence

    Description
    NM_198138.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and lacks homolog support.