Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    SIN3A SIN3 transcription regulator homolog A (yeast) [ Homo sapiens (human) ]

    Gene ID: 25942, updated on 15-May-2013
    Official Symbol
    SIN3Aprovided by HGNC
    Official Full Name
    SIN3 transcription regulator homolog A (yeast)provided by HGNC
    Primary source
    HGNC:19353
    See related
    Ensembl:ENSG00000169375; HPRD:09690; MIM:607776; Vega:OTTHUMG00000142834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
    Location :
    15q24.2
    Sequence :
    Chromosome: 15; NC_000015.9 (75661720..75748124, complement)
    See SIN3A in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene nei endonuclease VIII-like 1 (E. coli) Neighboring gene microRNA 631 Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene ribosomal protein L13 pseudogene 4 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene snurportin 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. Steunou AL, et al. Mol Cell Proteomics, 2013 Mar. PMID 23275444.
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    3. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. Wu Z, et al. PLoS One, 2012. PMID 22952844.
    4. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    5. The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Icardi L, et al. Proc Natl Acad Sci U S A, 2012 Jul 24. PMID 22783022.

    See all (226) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The Sin3a complex acts as a context-dependent ISGF3/STAT3 transcriptional switch.
      Title: The Sin3a repressor complex is a master regulator of STAT transcriptional activity.
    2. Ume6 is a negative regulator of ATG8 transcription, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels
      Title: Ume6 transcription factor is part of a signaling cascade that regulates autophagy.
    3. Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation.(
      Title: Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation.
    4. Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that Gon4l may function as a platform for the assembly of complexes that regulate gene expression.
      Title: The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.
    5. The study identifies Sin3A as a regulator of gene expression, survival, and growth in ERalpha-positive breast cancer cells.
      Title: Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor.
    6. sumoylation of ING2 enhances its binding to the Sin3A/HDAC complex and is required to regulate gene transcriptions
      Title: Sumoylation of ING2 regulates the transcription mediated by Sin3A.
    7. disruption of the function of a specific Sin3A/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells
      Title: Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells.
    8. Resullts show that SHP and Sin3A play an important role in adamantyl-substituted retinoid-related induction of cellular apoptosis.
      Title: SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis.
    9. These data support a model of repression wherein actions of ERalpha and Sin3A at the proximal promoter can overcome activating signals at distal or proximal sites and ultimately decrease gene expression.
      Title: Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter.
    10. A novel regulatory signaling mechanism of transcriptional control in which the LHR is derepressed through PKCalpha/ERK-mediated Sp1 phosphorylation, causing the release of HDAC1/mSin3A complex from the promoter.
      Title: Protein kinase Calpha-induced derepression of the human luteinizing hormone receptor gene transcription through ERK-mediated release of HDAC1/Sin3A repressor complex from Sp1 sites.
    Submit: New GeneRIF Correction See all (26)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Tat, p14 tat The SIN3/HDAC complex, composed of SIN3A, SAP30, SAP18, HDAC-1 AND -2 and RbAp46/48 except SAP30, are identified to interact with HIV-1 Tat in Jurkat cell PubMed
    pol gag-pol HIV-1 IN and INI1/hSNF5 bind SAP18 and selectively recruit components of Sin3a-HDAC1 complex into HIV-1 virions. HIV-1 virion-associated HDAC1 is required for efficient early post-entry events PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_056292.1 NP_004955.2 HDAC1    BIND  PubMed The transcriptional repressor mSin3A interacts with the histone deacetylase 1 protein. 
    NP_056292.1 NP_001518.1 HDAC2    BIND  PubMed The transcriptional repressor mSin3A interacts with histone deacetylase 2. 
    NP_056292.1 NP_002102.2 HTT    BIND  PubMed mSin3A interacts with htt. This interaction was modeled on a demonstrated interaction between mSin3A and htt from unspecified species. 
    NP_056292.1 NP_004340.1 RUNX1T1    BIND  PubMed ETO interacts with Sin3A. 
    NP_056292.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with mSin3A. This interaction was modeled on a demonstrated interaction between human p53 and mSin3A from an unspecified species. 
    NP_056292.1 NP_005997.2 ZBTB16    BIND  PubMed Sin3A interacts with PLZF. This interaction was modelled on a demonstrated interaction between mSin3A and PLZF from unspecified species. 
    NP_056292.1 AAB34819.2     BIND  PubMed AML1/ETO interacts with SIN3A. 
    NP_056292.1 AAG27458.1     BIND  PubMed LANA interacts with Sin3A 
    NP_056292.1 BAB62809.1     BIND  PubMed PML/RAR-alpha interacts with SIN3A. 
    Q96ST3 P29374 ARID4A    HPRD  PubMed  
    Q96ST3 RBP1 like protein ARID4B    HPRD  PubMed  
    Q96ST3 P41182 BCL6    HPRD  PubMed  
    Q96ST3 Q9HCU9 BRMS1    HPRD  PubMed  
    Q96ST3 Breast cancer metastasis suppressor 1 like BRMS1L    HPRD  PubMed  
    Q96ST3 O43439 CBFA2T2    HPRD  PubMed  
    Q96ST3 Q13363 CTBP1    HPRD  PubMed  
    Q96ST3 Q9UI36 DACH1    HPRD  PubMed  
    Q96ST3 Q9UHI6 DDX20    HPRD  PubMed  
    Q96ST3 Q7L2E3 DHX30    HPRD  PubMed  
    Q96ST3 P41212 ETV6    HPRD  PubMed  
    Q96ST3 O60381 HBP1    HPRD  PubMed  
    Q96ST3 P51610 HCFC1    HPRD  PubMed  
    Q96ST3 Q13547 HDAC1    HPRD  PubMed  
    Q96ST3 Q92769 HDAC2    HPRD  PubMed  
    Q96ST3 Q8WUI4 HDAC7    HPRD  PubMed  
    Q96ST3 Q9UKV0 HDAC9    HPRD  PubMed  
    Q96ST3 Q9UBP5 HEY2    HPRD  PubMed  
    Q96ST3 P42858 HTT    HPRD  PubMed  
    Q96ST3 Q13422 IKZF1    HPRD  PubMed  
    Q96ST3 Zinc finger protein, subfamily 1A, member 4 IKZF4    HPRD  PubMed  
    Q96ST3 Q9UK53 ING1    HPRD  PubMed  
    Q96ST3 O14901 KLF11    HPRD  PubMed  
    Q96ST3 Q9BXK1 KLF16    HPRD  PubMed  
    Q96ST3 O75427 LRCH4    HPRD  PubMed  
    Q96ST3 Q9Y6D9 MAD1L1    HPRD  PubMed  
    Q96ST3 Q9UBB5 MBD2    HPRD  PubMed  
    Q96ST3 P51608 MECP2    HPRD  PubMed  
    Q96ST3 Q99583 MNT    HPRD  PubMed  
    Q96ST3 Q15014 MORF4L2    HPRD  PubMed  
    Q96ST3 Q05195 MXD1    HPRD  PubMed  
    Q96ST3 Q14582 MXD4    HPRD  PubMed  
    Q96ST3 P50539 MXI1    HPRD  PubMed  
    Q96ST3 Q9Y5X4 NR2E3    HPRD  PubMed  
    Q96ST3 O15294 OGT    HPRD  PubMed  
    Q96ST3 Q9UQ80 PA2G4    HPRD  PubMed  
    Q96ST3 P35232 PHB    HPRD  PubMed  
    Q96ST3 Q96QT6 PHF12    HPRD  PubMed  
    Q96ST3 P29590 PML    HPRD  PubMed  
    Q96ST3 P06454 PTMA    HPRD  PubMed  
    Q96ST3 Q09028 RBBP4    HPRD  PubMed  
    Q96ST3 Q16576 RBBP7    HPRD  PubMed  
    Q96ST3 P09455 RBP1    HPRD  PubMed  
    Q96ST3 Q9NVW2 RLIM    HPRD  PubMed  
    Q96ST3 Q06455 RUNX1T1    HPRD  PubMed  
    Q96ST3 O75446 SAP30    HPRD  PubMed  
    Q96ST3 Q15047 SETDB1    HPRD  PubMed  
    Q96ST3 P23246 SFPQ    HPRD  PubMed  
    Q96ST3 P12755 SKI    HPRD  PubMed  
    Q96ST3 Q92922 SMARCC1    HPRD  PubMed  
    Q96ST3 P17542 TAL1    HPRD  PubMed  
    Q96ST3 Q15583 TGIF1    HPRD  PubMed  
    Q96ST3 P04637 TP53    HPRD  PubMed  
    Q96ST3 Q05516 ZBTB16    HPRD  PubMed  
    Q96ST3 Chromosome 2 open reading frame 59     HPRD  PubMed  
    BioGRID:117439 BioGRID:106566 ACO2    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:106631 ADD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:115987 AHCYL1    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:1147430 ALL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:111861 ARID4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:119708 ARID4B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117439 BioGRID:114497 BAZ1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:107076 BCL6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:129125 BCL6B    BioGRID  PubMed Two-hybrid 
    BioGRID:117439 BioGRID:114123 BHLHE40    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:117379 BRMS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:124038 BRMS1L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117439 BioGRID:117070 CABIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:114586 CBFA2T2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:107532 CHD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:107533 CHD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:114729 COPS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:107841 CSNK2A1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:117439 BioGRID:115906 CTCF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:130113 CYP4V2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:107972 DACH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:116571 DHX30    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117439 BioGRID:108126 DNMT3B    BioGRID  PubMed Co-purification 
    BioGRID:117439 BioGRID:108206 E2F4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:122306 EFCAB6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:108348 EPAS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117439 BioGRID:108421 ETV6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:109132 GPS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:109127 GRK5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:117927 HBP1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:117439 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification; Reconstituted Complex 
    BioGRID:117439 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:115083 HDAC9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:117045 HEY2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:109341 HINT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:207862 Hdac7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:109624 ID2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:109698 IGBP1    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:115604 IKZF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:116485 IKZF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:116484 IKZF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:122146 IKZF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:109833 ING1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117439 BioGRID:109834 ING2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117439 BioGRID:109871 IRF5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:114995 ISG15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:116667 KDM1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:124197 KDM2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:115904 KLF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112927 KLF10    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:114040 KLF11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:119642 KLF13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:123771 KLF16    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:107152 KLF9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:110443 KMT2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:115796 LAMTOR5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:110269 MAF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:114445 MBD2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:119788 MBD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:124569 MBD3L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:114444 MBD4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:110368 MECP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:110384 MEN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:115948 MGEA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:129453 MKX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:110478 MNT    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:116135 MORF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:115001 MORF4L2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:114562 MTA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117439 BioGRID:110259 MXD1    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:117439 BioGRID:123658 MXD3    BioGRID  PubMed Two-hybrid 
    BioGRID:117439 BioGRID:110687 MYB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:201270 Mad1l1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:204126 Morf4l1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:114974 NCOR2    BioGRID  PubMed Co-fractionation; Reconstituted Complex 
    BioGRID:117439 BioGRID:110857 NFKB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:110858 NFKB2    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:117439 BioGRID:110865 NFX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:110886 NKX2-2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:107055 NKX3-2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:110904 NONO    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:110915 NOTCH2    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:114012 NR0B2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:113033 NR2C1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:115320 NR2E3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:110983 NR4A2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:114049 OGT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:111075 PA2G4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:115857 PDLIM5    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:111226 PFDN5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:111238 PFN2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:111264 PHB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:121686 PHF12    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:115688 PRMT5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:111724 PTMA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:111837 RAN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:111863 RBBP4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:111866 RBBP7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:109736 RBPJ    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:111898 REL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:117439 BioGRID:111903 RELB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:111910 REST    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:119319 RLIM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:107310 RUNX1T1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:203038 Rxra    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:112189 S100A10    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:122735 SAP130    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:117439 BioGRID:115573 SAP18    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:941018 SAP25    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:114346 SAP30    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex 
    BioGRID:117439 BioGRID:122808 SAP30L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:112211 SATB1    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:114926 SEC22B    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:120870 SEPT11    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:115202 SETDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:113368 SF1    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:112319 SFPQ    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:117439 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:112389 SKIL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:114754 SLC9A3R2    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:110263 SMAD3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:117439 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:117439 BioGRID:114045 SMARCA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:117439 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:112485 SMARCC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112489 SMARCE1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112506 SNCA    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:117439 BioGRID:116597 SNW1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:112540 SOX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112566 SPI1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:122174 SUDS3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:112723 SYT1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:116740 TAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:112735 TAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112741 TAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112743 TAF9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:112770 TBL1X    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112771 TBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112791 TCF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:112882 TFCP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:112908 TGIF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:121972 THADA    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:121453 THAP11    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:127001 TOM1L2    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:117439 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:117439 BioGRID:115457 TRIM28    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:116782 TTLL12    BioGRID  PubMed Co-fractionation 
    BioGRID:117439 BioGRID:204183 Thra    BioGRID  PubMed Reconstituted Complex 
    BioGRID:117439 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:117439 BioGRID:113264 VDR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:113306 WHSC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:113498 ZBTB16    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:117439 BioGRID:121693 ZBTB4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:119488 ZBTB7A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:117439 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ90319, KIAA0700, DKFZp434K2235

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		  
    RNA polymerase II repressing transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription corepressor activity RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		  
    aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cellular lipid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    interphase of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of histone H3-K27 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of transcription regulatory region DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of chromatin silencing IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		  
    protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to methylglyoxal IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic nitrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Sin3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Sin3 complex NAS
    Non-traceable Author Statement
    more info
    		  
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcriptional repressor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    paired amphipathic helix protein Sin3a
    Names
    paired amphipathic helix protein Sin3a
    transcriptional regulator, SIN3A
    transcriptional corepressor Sin3a
    transcriptional co-repressor Sin3A
    SIN3 homolog A, transcription regulator
    histone deacetylase complex subunit Sin3a

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145357.1 → NP_001138829.1  paired amphipathic helix protein Sin3a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC068338, AF418569, AL832463, BM676304
      Consensus CDS
      CCDS10279.1
      UniProtKB/Swiss-Prot
      Q96ST3
      Conserved Domains (3) summary
      COG5602
      Location:8 – 822
      Blast Score: 1119
      SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
      pfam08295
      Location:550 – 650
      Blast Score: 456
      Sin3_corepress; Sin3 family co-repressor
      pfam02671
      Location:141 – 187
      Blast Score: 197
      PAH; Paired amphipathic helix repeat

    2. NM_001145358.1 → NP_001138830.1  paired amphipathic helix protein Sin3a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC068338, AF418569, AK096477, BM676304, DB074084
      Consensus CDS
      CCDS10279.1
      UniProtKB/Swiss-Prot
      Q96ST3
      Related
      ENSP00000378402, OTTHUMP00000183517, ENST00000394947, OTTHUMT00000286469
      Conserved Domains (3) summary
      COG5602
      Location:8 – 822
      Blast Score: 1119
      SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
      pfam08295
      Location:550 – 650
      Blast Score: 456
      Sin3_corepress; Sin3 family co-repressor
      pfam02671
      Location:141 – 187
      Blast Score: 197
      PAH; Paired amphipathic helix repeat

    3. NM_015477.2 → NP_056292.1  paired amphipathic helix protein Sin3a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC068338, AF418569, BC041047, BM676304
      Consensus CDS
      CCDS10279.1
      UniProtKB/Swiss-Prot
      Q96ST3
      Conserved Domains (3) summary
      COG5602
      Location:8 – 822
      Blast Score: 1119
      SIN3; Histone deacetylase complex, SIN3 component [Chromatin structure and dynamics]
      pfam08295
      Location:550 – 650
      Blast Score: 456
      Sin3_corepress; Sin3 family co-repressor
      pfam02671
      Location:141 – 187
      Blast Score: 197
      PAH; Paired amphipathic helix repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p10 Primary Assembly

      Range
      75661720..75748124, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      52420097..52506377, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018926.1 Alternate CHM1_1.0

      Range
      55713546..55799717, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01060522.1 (20875..91138) None
    genomic ABBA01060523.1 None
    genomic ABBA01060524.1 None
    genomic ABBA01060525.1 None
    genomic AC068338.14 None
    genomic AC105137.18 (66169..142008) None
    genomic AMYH01006814.1 (76564..162735) None
    genomic CH471136.2 EAW99249.1
      EAW99250.1
      EAW99251.1
    mRNA AF418569.1 AAP97288.1
    mRNA AK027559.1 BAB55197.1
    mRNA AK074800.1 BAG52005.1
    mRNA AK074903.1 BAC11280.1
    mRNA AK096477.1 BAC04801.1
    mRNA AL117513.1 CAB55972.1
    mRNA AL832463.1 None
    mRNA AY044430.1 AAK95854.1
    mRNA BC018973.1 AAH18973.1
    mRNA BC030563.1 None
    mRNA BC041047.1 None
    mRNA BC052275.1 None
    mRNA BC066364.1 None
    mRNA BC137098.1 AAI37099.1
    mRNA BC137099.1 AAI37100.1
    mRNA BM676304.1 None
    mRNA BX649162.1 None
    mRNA DB074084.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96ST3.2 GenPept UniProtKB/Swiss-Prot:Q96ST3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioAssays, RNAi Target,Active
        BioAssays, RNAi Target,Active
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...