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Srgap3 SLIT-ROBO Rho GTPase activating protein 3 [ Mus musculus (house mouse) ]

Gene ID: 259302, updated on 22-May-2016
Official Symbol
Srgap3provided by MGI
Official Full Name
SLIT-ROBO Rho GTPase activating protein 3provided by MGI
Primary source
MGI:MGI:2152938
See related
Ensembl:ENSMUSG00000030257 Vega:OTTMUSG00000022682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbi; WRP; MEGAP; AI452337; Arhgap14; mKIAA0411; D130026O08Rik
Orthologs
Location:
6; 6 E3
Exon count:
24
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (112717971..112947444, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (112667965..112897260, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35824 Neighboring gene predicted gene, 26799 Neighboring gene Yip1 interacting factor homolog A pseudogene Neighboring gene ribosomal protein S29 pseudogene Neighboring gene ribosomal protein L21 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Rac GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
SLIT-ROBO Rho GTPase-activating protein 3
Names
SLIT-ROBO Rho GTPase activating protein 2
WAVE-associated Rac GTPase-activating protein
brain stress early protein Gbi
rho GTPase activating protein 14
rho GTPase-activating protein 14
srGAP2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080448.4NP_536696.4  SLIT-ROBO Rho GTPase-activating protein 3

    See identical proteins and their annotated locations for NP_536696.4

    Status: VALIDATED

    Source sequence(s)
    AC153591, AK051262, AY057899, CF744803, CK032058
    Consensus CDS
    CCDS39590.1
    UniProtKB/Swiss-Prot
    Q812A2
    UniProtKB/TrEMBL
    F8VPQ4, Q91Z68
    Related
    ENSMUSP00000085712, OTTMUSP00000025951, ENSMUST00000088373, OTTMUST00000054370
    Conserved Domains (4) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:748800
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:502689
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    112717971..112947444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506145.1XP_006506208.1  

    UniProtKB/TrEMBL
    E9QN14
    Related
    ENSMUSP00000108794, OTTMUSP00000049839, ENSMUST00000113169, OTTMUST00000090761
    Conserved Domains (4) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:724776
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:481665
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK
  2. XM_006506144.1XP_006506207.1  

    Conserved Domains (4) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:753805
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:510694
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK
  3. XM_006506146.1XP_006506209.1  

    Conserved Domains (4) summary
    cd07684
    Location:26278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:753805
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:510694
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK
  4. XM_006506147.2XP_006506210.1  

    Conserved Domains (2) summary
    pfam02120
    Location:350400
    Flg_hook; Flagellar hook-length control protein FliK
    cl12013
    Location:26278
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    114543131..114774424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153070.1: Suppressed sequence

    Description
    NM_153070.1: This RefSeq was permanently suppressed because it was entirely 3' UTR sequence.