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WFDC9 WAP four-disulfide core domain 9 [ Homo sapiens (human) ]

Gene ID: 259240, updated on 17-Feb-2015
Official Symbol
WFDC9provided by HGNC
Official Full Name
WAP four-disulfide core domain 9provided by HGNC
Primary source
HGNC:HGNC:20380
See related
Ensembl:ENSG00000180205; HPRD:15678; Vega:OTTHUMG00000046332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WAP9; dJ688G8.2
Summary
The WAP-type four-disulfide core (WFDC) domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many members of the WFDC domain family. This gene encodes a protein which contains a WFDC domain, and is thus a member of the WFDC domain family. This gene and several other gene family members are clustered at 20q13.12. [provided by RefSeq, Jul 2008]
Orthologs
See WFDC9 in MapViewer
Location:
20q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (45607939..45631268, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44236578..44259907, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 8 Neighboring gene RNA, 5S ribosomal pseudogene 485 Neighboring gene cyclin B1 interacting protein 1 pseudogene 2 Neighboring gene WAP four-disulfide core domain 10A Neighboring gene ribosomal protein S2 pseudogene 7 Neighboring gene WAP four-disulfide core domain 11

Replication interactions

Interaction Pubs
Knockdown of WAP four-disulfide core domain 9 (WFDC9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126701, MGC126705

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein WFDC9
Names
protein WFDC9

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147198.3NP_671731.1  protein WFDC9 precursor

    See proteins identical to NP_671731.1

    Status: VALIDATED

    Source sequence(s)
    AW269752, AY047610
    Consensus CDS
    CCDS13362.1
    UniProtKB/Swiss-Prot
    Q8NEX5
    Related
    ENSP00000320532, OTTHUMP00000043660, ENST00000326000, OTTHUMT00000106945

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38 Primary Assembly

    Range
    45607939..45631268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    44139303..44162632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 Alternate HuRef

    Range
    40978043..41001367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)