Format

Send to:

Choose Destination

NELFB negative elongation factor complex member B [ Homo sapiens (human) ]

Gene ID: 25920, updated on 8-May-2016
Official Symbol
NELFBprovided by HGNC
Official Full Name
negative elongation factor complex member Bprovided by HGNC
Primary source
HGNC:HGNC:24324
See related
Ensembl:ENSG00000188986 HPRD:10845; MIM:611180; Vega:OTTHUMG00000131778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COBRA1; NELF-B
Summary
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
9q34
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (137255307..137273548)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140149759..140168000)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene tubulin beta 4B class IVb Neighboring gene family with sequence similarity 166 member A Neighboring gene C9orf173 antisense RNA 1 Neighboring gene sperm-tail PG-rich repeat containing 3 Neighboring gene torsin family 4 member A Neighboring gene NOTCH-regulated ankyrin repeat protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of NELF-B by shRNA enhances HIV-1 transcription in latently infected cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat NELF represses HIV-1 transcription by pausing the RNA polymerase II complex PubMed
tat NELF associates with HIV-1 Tat as part of the HIV-1 transcription elongation complex PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • KIAA1182, DKFZp586B0519

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
NELF complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
negative elongation factor B
Names
cofactor of BRCA1
negative elongation factor protein B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015456.4NP_056271.3  negative elongation factor B

    Status: VALIDATED

    Source sequence(s)
    AK022651, AL050280, BC019029, CT003266, DA210427
    Consensus CDS
    CCDS7040.1
    UniProtKB/Swiss-Prot
    Q8WX92
    Related
    ENSP00000489248, ENST00000634710
    Conserved Domains (1) summary
    pfam06209
    Location:154628
    COBRA1; Cofactor of BRCA1 (COBRA1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    137255307..137273548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    140298493..140316577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)