These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_029185.1 RefSeqGene
- Range
- 5001..241209
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001242767.1 → NP_001229696.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 1 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
BC110319, BC144368, DB727926
- UniProtKB/TrEMBL
-
B7ZM99
- UniProtKB/Swiss-Prot
-
Q6UB35
- Conserved Domains (4) summary
-
- cd00477
Location:378 – 962
Blast Score: 2002
- FTHFS; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2 ...
- cd05212
Location:193 – 336
Blast Score: 536
- NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
- PLN02759
Location:353 – 979
Blast Score: 2492
- PLN02759; Formate--tetrahydrofolate ligase
- pfam00763
Location:74 – 180
Blast Score: 202
- THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
-
NM_001242768.1 → NP_001229697.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
- Source sequence(s)
-
AK315378, BC110319, DA195967
- UniProtKB/TrEMBL
-
B2RD24
- UniProtKB/Swiss-Prot
-
Q6UB35
- Conserved Domains (4) summary
-
- cd00477
Location:312 – 896
Blast Score: 2002
- FTHFS; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2 ...
- cd05212
Location:127 – 270
Blast Score: 537
- NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
- PLN02759
Location:287 – 913
Blast Score: 2497
- PLN02759; Formate--tetrahydrofolate ligase
- pfam00763
Location:10 – 114
Blast Score: 198
- THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
-
NM_001242769.1 → NP_001229698.1 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 4 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus and lacks a single internal aa compared to isoform 1. Isoform 4 is thought to lack THF synthase activity.
- Source sequence(s)
-
AW593866, AY374131, DB727926
- Consensus CDS
-
CCDS56457.1
- UniProtKB/Swiss-Prot
-
Q6UB35
- Related
- ENSP00000356276, ENST00000367307
- Conserved Domains (2) summary
-
- pfam00763
Location:74 – 180
Blast Score: 196
- THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
- cl09931
Location:193 – 260
Blast Score: 275
- NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
-
NM_015440.4 → NP_056255.2 monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 2 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
- Source sequence(s)
-
AY374130, BC110319, DB727926
- Consensus CDS
-
CCDS5228.1
- UniProtKB/Swiss-Prot
-
Q6UB35
- Related
- ENSP00000356290, OTTHUMP00000017418, ENST00000367321, OTTHUMT00000042699
- Conserved Domains (4) summary
-
- cd00477
Location:377 – 961
Blast Score: 2002
- FTHFS; Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2 ...
- cd05212
Location:193 – 335
Blast Score: 548
- NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
- PLN02759
Location:352 – 978
Blast Score: 2492
- PLN02759; Formate--tetrahydrofolate ligase
- pfam00763
Location:74 – 180
Blast Score: 202
- THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000006.11 Reference GRCh37.p5 Primary Assembly
- Range
- 151186815..151423023
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000138.1 Alternate HuRef
- Range
- 148750394..148986848
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)