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ASF1A anti-silencing function 1A histone chaperone [ Homo sapiens (human) ]

Gene ID: 25842, updated on 29-May-2016
Official Symbol
ASF1Aprovided by HGNC
Official Full Name
anti-silencing function 1A histone chaperoneprovided by HGNC
Primary source
HGNC:HGNC:20995
See related
Ensembl:ENSG00000111875 HPRD:16459; MIM:609189; Vega:OTTHUMG00000015470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIA; CGI-98; HSPC146
Summary
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6q22.31
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (118894077..118909171)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (119215241..119230336)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 like Neighboring gene uncharacterized LOC105377969 Neighboring gene selenoprotein K pseudogene Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene family with sequence similarity 184 member A Neighboring gene microRNA 548b Neighboring gene uncharacterized LOC105377974 Neighboring gene mannosidase alpha class 1A member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants at ten loci influence QT interval duration in the QTGEN Study.
NHGRI GWA Catalog
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • DNA Damage/Telomere Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    DNA Damage/Telomere Stress Induced Senescence, organism-specific biosystemReactive oxygen species (ROS), whose concentration increases in senescent cells due to oncogenic RAS-induced mitochondrial dysfunction (Moiseeva et al. 2009) or due to environmental stress, cause DNA...
  • Formation of Senescence-Associated Heterochromatin Foci (SAHF), organism-specific biosystem (from REACTOME)
    Formation of Senescence-Associated Heterochromatin Foci (SAHF), organism-specific biosystemThe process of DNA damage/telomere stress induced senescence culminates in the formation of senescence associated heterochromatin foci (SAHF). These foci represent facultative heterochromatin that is...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp547E2110

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding NAS
Non-traceable Author Statement
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chromatin silencing NAS
Non-traceable Author Statement
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
histone chaperone ASF1A
Names
ASF1 anti-silencing function 1 homolog A
CCG1-interacting factor A
anti-silencing function protein 1 homolog A
hAsf1
hAsf1a
hCIA

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014034.2NP_054753.1  histone chaperone ASF1A

    See identical proteins and their annotated locations for NP_054753.1

    Status: REVIEWED

    Source sequence(s)
    AA481056, AK025738, DA902777
    Consensus CDS
    CCDS47469.1
    UniProtKB/Swiss-Prot
    Q9Y294
    Related
    ENSP00000229595, OTTHUMP00000218808, ENST00000229595, OTTHUMT00000361910
    Conserved Domains (1) summary
    pfam04729
    Location:1154
    ASF1_hist_chap; ASF1 like histone chaperone

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    118894077..118909171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    119479284..119494377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)