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PRDX5 peroxiredoxin 5 [ Homo sapiens (human) ]

Gene ID: 25824, updated on 26-May-2016
Official Symbol
PRDX5provided by HGNC
Official Full Name
peroxiredoxin 5provided by HGNC
Primary source
HGNC:HGNC:9355
See related
Ensembl:ENSG00000126432 HPRD:05958; MIM:606583; Vega:OTTHUMG00000168805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLP; ACR1; B166; PRXV; PMP20; PRDX6; prx-V; SBBI10; AOEB166; HEL-S-55
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11q13
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (64318088..64321823)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64085347..64089295)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene testis expressed 40 Neighboring gene estrogen related receptor alpha Neighboring gene tRNA methyltransferase 11-2 homolog (S. cerevisiae) Neighboring gene uncharacterized LOC102723878 Neighboring gene coiled-coil domain containing 88B Neighboring gene microRNA 7155

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
NHGRI GWA Catalog
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Detoxification of Reactive Oxygen Species, organism-specific biosystem (from REACTOME)
    Detoxification of Reactive Oxygen Species, organism-specific biosystemReactive oxygen species such as superoxide (O2.-), peroxides (ROOR), singlet oxygen, peroxynitrite (ONOO-), and hydroxyl radical (OH.) are generated by cellular processes such as respiration (reviewe...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Selenium Pathway, organism-specific biosystem (from WikiPathways)
    Selenium Pathway, organism-specific biosystem
    Selenium Pathway
  • TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Metabolic Genes, organism-specific biosystemWhile the p53 tumor suppressor protein (TP53) is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cel...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • thioredoxin pathway, organism-specific biosystem (from BIOCYC)
    thioredoxin pathway, organism-specific biosystem
    thioredoxin pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117264, MGC142283, MGC142285

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase III regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peroxiredoxin activity IDA
Inferred from Direct Assay
more info
PubMed 
peroxynitrite reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioredoxin peroxidase activity EXP
Inferred from Experiment
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
peroxiredoxin-5, mitochondrial
Names
Alu co-repressor 1
TPx type VI
antioxidant enzyme B166
epididymis secretory protein Li 55
liver tissue 2D-page spot 71B
peroxiredoxin V
peroxisomal antioxidant enzyme
thioredoxin peroxidase PMP20
thioredoxin reductase
NP_036226.1
NP_857634.1
NP_857635.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012094.4NP_036226.1  peroxiredoxin-5, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_036226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (a).
    Source sequence(s)
    AA187737, BC110983
    Consensus CDS
    CCDS8069.1
    UniProtKB/Swiss-Prot
    P30044
    Related
    ENSP00000265462, OTTHUMP00000239506, ENST00000265462, OTTHUMT00000401148
    Conserved Domains (1) summary
    cd03013
    Location:58212
    PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
  2. NM_181651.2NP_857634.1  peroxiredoxin-5, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_857634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (b) contains a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA187737, BC110983, BC143849
    Consensus CDS
    CCDS8070.1
    UniProtKB/Swiss-Prot
    P30044
    Related
    ENSP00000335334, OTTHUMP00000239507, ENST00000352435, OTTHUMT00000401149
    Conserved Domains (1) summary
    cl00388
    Location:58168
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. NM_181652.2NP_857635.1  peroxiredoxin-5, mitochondrial isoform c precursor

    See identical proteins and their annotated locations for NP_857635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (c) contains a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA187737, BC110983, BC171733
    Consensus CDS
    CCDS8071.1
    UniProtKB/Swiss-Prot
    P30044
    Related
    ENSP00000335363, OTTHUMP00000239508, ENST00000347941, OTTHUMT00000401150
    Conserved Domains (1) summary
    cl00388
    Location:57123
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    64318088..64321823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273882.3XP_005273939.2  

    Conserved Domains (1) summary
    cd03013
    Location:57167
    PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    63968573..63972308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)