Format

Send to:

Choose Destination

NOCT nocturnin [ Homo sapiens (human) ]

Gene ID: 25819, updated on 12-May-2016
Official Symbol
NOCTprovided by HGNC
Official Full Name
nocturninprovided by HGNC
Primary source
HGNC:HGNC:14254
See related
Ensembl:ENSG00000151014 HPRD:16337; MIM:608468; Vega:OTTHUMG00000161271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOC; CCR4L; Ccr4c; CCRN4L
Summary
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]
Orthologs
Location:
4q31.1
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (139015759..139045939)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (139936913..139967093)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NIN1/PSMD8 binding protein 1 homolog pseudogene Neighboring gene uncharacterized LOC105377448 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 3 Neighboring gene E74 like ETS transcription factor 2 Neighboring gene mitochondria localized glutamic acid rich protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC78549, MGC142054, MGC142060, MGC4120817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor activity, sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm TAS
Traceable Author Statement
more info
 
cytoplasmic mRNA processing body assembly IEA
Inferred from Electronic Annotation
more info
 
deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to extracellular stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic mRNA processing body IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
nocturnin
Names
CCR4 carbon catabolite repression 4-like
CCR4 protein homolog
CCR4-like (carbon catabolite repression 4, S.cerevisiae)
carbon catabolite repression 4-like protein
circadian deadenylase NOC
NP_036250.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012118.3NP_036250.2  nocturnin

    See identical proteins and their annotated locations for NP_036250.2

    Status: REVIEWED

    Source sequence(s)
    AC093602, BC113494, HY067201
    Consensus CDS
    CCDS3743.1
    UniProtKB/Swiss-Prot
    Q9UK39
    Related
    ENSP00000280614, OTTHUMP00000164538, ENST00000280614, OTTHUMT00000257231
    Conserved Domains (1) summary
    cd09096
    Location:144423
    Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    139015759..139045939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    139914539..139944403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)