Format

Send to:

Choose Destination

KLK5 kallikrein related peptidase 5 [ Homo sapiens (human) ]

Gene ID: 25818, updated on 15-May-2016
Official Symbol
KLK5provided by HGNC
Official Full Name
kallikrein related peptidase 5provided by HGNC
Primary source
HGNC:HGNC:6366
See related
Ensembl:ENSG00000167754 HPRD:05732; MIM:605643; Vega:OTTHUMG00000183097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCTE; KLKL2; KLK-L2
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Orthologs
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (50943299..50953088, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51446559..51456344, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 4 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene Neighboring gene uncharacterized LOC105372442 Neighboring gene kallikrein related peptidase 6 Neighboring gene kallikrein related peptidase 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
epidermis development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of G-protein coupled receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of antibacterial peptide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
epidermal lamellar body IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
kallikrein-5
Names
kallikrein 5
kallikrein-like protein 2
kallikrein-related peptidase 5
stratum corneum tryptic enzyme

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077491.1NP_001070959.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_001070959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AY279381, AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    Q9Y337
    UniProtKB/TrEMBL
    A0A024R4G4
    Related
    ENSP00000375685, OTTHUMP00000270841, ENST00000391809, OTTHUMT00000465067
    Conserved Domains (2) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:67288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001077492.1NP_001070960.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_001070960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    Q9Y337
    UniProtKB/TrEMBL
    A0A024R4G4
    Related
    ENSP00000471966, OTTHUMP00000270833, ENST00000593428, OTTHUMT00000465056
    Conserved Domains (2) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:67288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_012427.4NP_036559.1  kallikrein-5 preproprotein

    See identical proteins and their annotated locations for NP_036559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AY359010
    Consensus CDS
    CCDS12810.1
    UniProtKB/Swiss-Prot
    Q9Y337
    UniProtKB/TrEMBL
    A0A024R4G4
    Related
    ENSP00000337733, OTTHUMP00000270834, ENST00000336334, OTTHUMT00000465057
    Conserved Domains (2) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:67288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    50943299..50953088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526702.1XP_011525004.1  

    See identical proteins and their annotated locations for XP_011525004.1

    UniProtKB/Swiss-Prot
    Q9Y337
    UniProtKB/TrEMBL
    A0A024R4G4
    Conserved Domains (2) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:67288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_011526703.1XP_011525005.1  

    See identical proteins and their annotated locations for XP_011525005.1

    UniProtKB/Swiss-Prot
    Q9Y337
    UniProtKB/TrEMBL
    A0A024R4G4
    Conserved Domains (2) summary
    smart00020
    Location:66285
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:67288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    51448041..51457829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)