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QPCT glutaminyl-peptide cyclotransferase [ Homo sapiens (human) ]

Gene ID: 25797, updated on 26-May-2016
Official Symbol
QPCTprovided by HGNC
Official Full Name
glutaminyl-peptide cyclotransferaseprovided by HGNC
Primary source
HGNC:HGNC:9753
See related
Ensembl:ENSG00000115828 HPRD:06140; MIM:607065; Vega:OTTHUMG00000100963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QC; GCT; sQC
Summary
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2p22.2
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (37344610..37373322)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37571742..37600465)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein kinase D3 Neighboring gene uncharacterized LOC101929542 Neighboring gene uncharacterized LOC105374464 Neighboring gene CDC42 effector protein 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutaminyl-peptide cyclotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glutaminyl-peptide cyclotransferase
Names
EC
glutaminyl cyclase
glutaminyl-tRNA cyclotransferase
glutamyl cyclase
NP_036545.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012413.3NP_036545.1  glutaminyl-peptide cyclotransferase precursor

    See identical proteins and their annotated locations for NP_036545.1

    Status: REVIEWED

    Source sequence(s)
    BC020456, BC047756, BF970452, BI755122
    Consensus CDS
    CCDS1790.1
    UniProtKB/Swiss-Prot
    Q16769
    Related
    ENSP00000344829, OTTHUMP00000126955, ENST00000338415, OTTHUMT00000218572
    Conserved Domains (1) summary
    cd03880
    Location:51358
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    37344610..37373322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    37501200..37529906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)