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PGLS 6-phosphogluconolactonase [ Homo sapiens (human) ]

Gene ID: 25796, updated on 8-May-2016
Official Symbol
PGLSprovided by HGNC
Official Full Name
6-phosphogluconolactonaseprovided by HGNC
Primary source
HGNC:HGNC:8903
See related
Ensembl:ENSG00000130313 HPRD:12001; MIM:604951; Vega:OTTHUMG00000182879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
6PGL; HEL-S-304
Orthologs
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (17511623..17521288)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17622278..17632097)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene nucleoredoxin-like 1 Neighboring gene solute carrier family 27 member 1 Neighboring gene family with sequence similarity 129 member C Neighboring gene collagen beta(1-O)galactosyltransferase 1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
6-phosphogluconolactonase activity EXP
Inferred from Experiment
more info
PubMed 
6-phosphogluconolactonase activity IDA
Inferred from Direct Assay
more info
PubMed 
monosaccharide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
pentose-phosphate shunt TAS
Traceable Author Statement
more info
 
pentose-phosphate shunt, oxidative branch IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
6-phosphogluconolactonase
Names
epididymis secretory protein Li 304
NP_036220.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012088.2NP_036220.1  6-phosphogluconolactonase

    See identical proteins and their annotated locations for NP_036220.1

    Status: VALIDATED

    Source sequence(s)
    AJ243972, BG764228
    Consensus CDS
    CCDS12361.1
    UniProtKB/Swiss-Prot
    O95336
    UniProtKB/TrEMBL
    A0A0K0K1K7
    Related
    ENSP00000252603, OTTHUMP00000270401, ENST00000252603, OTTHUMT00000464154
    Conserved Domains (1) summary
    cd01400
    Location:16240
    6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    17511623..17521288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527897.1XP_011526199.1  

    Conserved Domains (1) summary
    cd01400
    Location:10152
    6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    17621814..17631479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)