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    PGLS 6-phosphogluconolactonase [ Homo sapiens ]

    Gene ID: 25796, updated on 19-May-2012
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    Summary

    Official Symbol
    PGLSprovided by HGNC
    Official Full Name
    6-phosphogluconolactonaseprovided by HGNC
    Primary source
    HGNC:8903
    See related
    Ensembl:ENSG00000130313; HPRD:12001; MIM:604951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    6PGL
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    Genomic context

    Location :
    19p13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (17622432..17632097)
    See PGLS in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene nucleoredoxin-like 1 Neighboring gene solute carrier family 27 (fatty acid transporter), member 1 Neighboring gene uncharacterized LOC100507551 Neighboring gene family with sequence similarity 129, member C Neighboring gene glycosyltransferase 25 domain containing 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See all (7) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O95336 Q01844 EWSR1    HPRD  PubMed  
    O95336 Q99750 MDFI    HPRD  PubMed  
    O95336 O15162 PLSCR1    HPRD  PubMed  
    BioGRID:117328 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:117328 BioGRID:110353 MDFI    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:117328 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:117328 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the PGLS gene: The PGLS gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    6-phosphogluconolactonase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    monosaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    pentose-phosphate shunt IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    pentose-phosphate shunt TAS
    Traceable Author Statement
    more info
    		  
    pentose-phosphate shunt, oxidative branch IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    6-phosphogluconolactonase
    Names
    6-phosphogluconolactonase
    NP_036220.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012088.2 → NP_036220.1  6-phosphogluconolactonase

      Status: VALIDATED

      Source sequence(s)
      AJ243972, BG764228
      Consensus CDS
      CCDS12361.1
      UniProtKB/Swiss-Prot
      O95336
      Related
      ENSP00000252603, ENST00000252603
      Conserved Domains (1) summary
      cd01400
      Location:72 – 240
      Blast Score: 565
      6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      17622432..17632097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      17187513..17197177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC010618.9 (21861..31526) None
    genomic CH471106.1 EAW84613.1
      EAW84614.1
    mRNA AF091091.1 AAC72960.1
    mRNA AJ243972.1 CAB57866.1
    mRNA BC014006.2 AAH14006.1
    mRNA BC017706.1 None
    mRNA BG764228.1 None
    other-genetic DQ893462.2 ABM84388.1
    other-genetic DQ896322.2 ABM87321.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95336.2 GenPept UniProtKB/Swiss-Prot:O95336
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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