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Pcna proliferating cell nuclear antigen [ Rattus norvegicus (Norway rat) ]

Gene ID: 25737, updated on 26-May-2016
Official Symbol
Pcnaprovided by RGD
Official Full Name
proliferating cell nuclear antigenprovided by RGD
Primary source
RGD:3269
See related
Ensembl:ENSRNOG00000021264
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
PCNAR; Pcna/cyclin
Summary
cell cycle protein that may contribute to the repair of DNA damage and to cell proliferation caused by exposure to pulmonary toxicants; may influence cell survival in ischaemically compromised tissue [RGD, Feb 2006]
Orthologs
Location:
3q36
Exon count:
6
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (124880698..124884570, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (131376235..131380108, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 23 member 2 Neighboring gene choline/ethanolamine kinase-like Neighboring gene transmembrane protein 230 Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene prokineticin receptor 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA polymerase binding IEA
Inferred from Electronic Annotation
more info
 
DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
MutLalpha complex binding IEA
Inferred from Electronic Annotation
more info
 
MutLalpha complex binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
damaged DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
dinucleotide insertion or deletion binding IEA
Inferred from Electronic Annotation
more info
 
dinucleotide insertion or deletion binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone acetyltransferase binding IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
purine-specific mismatch base pair DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
purine-specific mismatch base pair DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
base-excision repair, gap-filling ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
estrous cycle IEP
Inferred from Expression Pattern
more info
PubMed 
heart development IEP
Inferred from Expression Pattern
more info
PubMed 
leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 
mismatch repair ISO
Inferred from Sequence Orthology
more info
 
mitotic telomere maintenance via semi-conservative replication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of deoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of deoxyribonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
replication fork processing ISO
Inferred from Sequence Orthology
more info
 
response to L-glutamate IEP
Inferred from Expression Pattern
more info
PubMed 
response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipid IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
translesion synthesis ISO
Inferred from Sequence Orthology
more info
 
translesion synthesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
PCNA complex IBA
Inferred from Biological aspect of Ancestor
more info
 
PCNA complex ISO
Inferred from Sequence Orthology
more info
 
PCNA complex ISS
Inferred from Sequence or Structural Similarity
more info
 
PCNA-p21 complex ISO
Inferred from Sequence Orthology
more info
 
PCNA-p21 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cell ISO
Inferred from Sequence Orthology
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nuclear lamina ISO
Inferred from Sequence Orthology
more info
 
nuclear replication fork IEA
Inferred from Electronic Annotation
more info
 
nuclear replication fork ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
replication fork ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
proliferating cell nuclear antigen
Names
cyclin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022381.3NP_071776.1  proliferating cell nuclear antigen

    See identical proteins and their annotated locations for NP_071776.1

    Status: PROVISIONAL

    Source sequence(s)
    Y00047
    UniProtKB/Swiss-Prot
    P04961
    Related
    ENSRNOP00000028887, ENSRNOT00000028887
    Conserved Domains (2) summary
    cd00577
    Location:4256
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    TIGR00590
    Location:1259
    pcna; proliferating cell nuclear antigen (pcna)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    124880698..124884570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    118296567..118300439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)