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NEGR1 neuronal growth regulator 1 [ Homo sapiens (human) ]

Gene ID: 257194, updated on 15-May-2016
Official Symbol
NEGR1provided by HGNC
Official Full Name
neuronal growth regulator 1provided by HGNC
Primary source
HGNC:HGNC:17302
See related
Ensembl:ENSG00000172260 HPRD:14820; MIM:613173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ntra; KILON; IGLON4; DMML2433
Orthologs
Location:
1p31.1
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (71402942..72282847, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71868625..72748533, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 antisense RNA 2 (head to head) Neighboring gene zinc finger RANBP2-type containing 2 Neighboring gene microRNA 186 Neighboring gene NEGR1 intronic transcript 1 Neighboring gene uncharacterized LOC105378797 Neighboring gene ribosomal protein L31 pseudogene 12 Neighboring gene GDP dissociation inhibitor 2 pseudogene 2 Neighboring gene uncharacterized LOC105378796

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
NHGRI GWA Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
NHGRI GWA Catalog
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
NHGRI GWA Catalog
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC46680

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
single organismal cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
neuronal growth regulator 1
Names
IgLON family member 4
a kindred of IgLON
neurotractin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173808.2NP_776169.2  neuronal growth regulator 1 precursor

    See identical proteins and their annotated locations for NP_776169.2

    Status: VALIDATED

    Source sequence(s)
    AL354949, AL356600, AL359821, AL627317, AL645724
    Consensus CDS
    CCDS661.1
    UniProtKB/Swiss-Prot
    Q7Z3B1
    Related
    ENSP00000350364, OTTHUMP00000011267, ENST00000357731, OTTHUMT00000026722
    Conserved Domains (4) summary
    cd00096
    Location:243309
    Ig; Immunoglobulin domain
    smart00408
    Location:152210
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:231312
    IG_like; Immunoglobulin like
    cl11960
    Location:153207
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    71402942..72282847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541200.1XP_011539502.1  

    Conserved Domains (4) summary
    cd00096
    Location:243309
    Ig; Immunoglobulin domain
    smart00408
    Location:152210
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:231312
    IG_like; Immunoglobulin like
    cl11960
    Location:153207
    Ig; Immunoglobulin domain
  2. XM_011541201.1XP_011539503.1  

    See identical proteins and their annotated locations for XP_011539503.1

    Conserved Domains (3) summary
    smart00408
    Location:152210
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:47135
    IG_like; Immunoglobulin like
    cl11960
    Location:153207
    Ig; Immunoglobulin domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    71983975..72863635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)