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Ucp3 uncoupling protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25708, updated on 22-May-2016
Official Symbol
Ucp3provided by RGD
Official Full Name
uncoupling protein 3provided by RGD
Primary source
RGD:3933
See related
Ensembl:ENSRNOG00000017716
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes a proton leak across the inner mitochondrial membrane to uncouple oxidative phosphorylation; may reduce the concentration of reactive ozygen species in mitochondria [RGD, Feb 2006]
Orthologs
Location:
1q32
Exon count:
7
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165482912..165495895)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (171683566..171697139)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene protein phosphatase methylesterase 1 Neighboring gene C2 calcium-dependent domain containing 3 Neighboring gene uncharacterized LOC103691200 Neighboring gene uncoupling protein 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
hydrogen ion transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
oxidative phosphorylation uncoupler activity IEA
Inferred from Electronic Annotation
more info
 
oxidative phosphorylation uncoupler activity ISO
Inferred from Sequence Orthology
more info
 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
mitochondrial transport IEA
Inferred from Electronic Annotation
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to superoxide IDA
Inferred from Direct Assay
more info
PubMed 
response to superoxide ISO
Inferred from Sequence Orthology
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
mitochondrial uncoupling protein 3
Names
UCP 3
Uncoupling protein 3, mitochondrial
solute carrier family 25 member 9
uncoupling protein 3 (mitochondrial, proton carrier)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013167.2NP_037299.1  mitochondrial uncoupling protein 3

    See identical proteins and their annotated locations for NP_037299.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072546
    UniProtKB/Swiss-Prot
    P56499
    Related
    ENSRNOP00000024005, ENSRNOT00000024005
    Conserved Domains (2) summary
    PTZ00169
    Location:13298
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:109207
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    165482912..165495895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    152898320..152911676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)