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Dbh dopamine beta-hydroxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25699, updated on 8-May-2016
Official Symbol
Dbhprovided by RGD
Official Full Name
dopamine beta-hydroxylaseprovided by RGD
Primary source
RGD:2489
See related
Ensembl:ENSRNOG00000006641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
DOPBHY
Summary
oxidoreductase that catalyzes the conversion of 3,4 dihydroxyphenethylamine, ascorbate, and O(2) to noradrenaline, dehydroascorbate, and H(2) in norephinephrine biosynthesis [RGD, Feb 2006]
Orthologs
Location:
3p12
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5709236..5731895)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (11073477..11095363)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene ADAMTS-like 2 Neighboring gene family with sequence similarity 163, member B Neighboring gene sarcosine dehydrogenase Neighboring gene uncharacterized LOC102548789 Neighboring gene uncharacterized LOC103691757

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
associative learning ISO
Inferred from Sequence Orthology
more info
 
behavioral response to ethanol IEA
Inferred from Electronic Annotation
more info
 
behavioral response to ethanol ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
bone development IEP
Inferred from Expression Pattern
more info
PubMed 
catecholamine metabolic process IC
Inferred by Curator
more info
PubMed 
cellular response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
cytokine production IEA
Inferred from Electronic Annotation
more info
 
cytokine production ISO
Inferred from Sequence Orthology
more info
 
dopamine catabolic process IEA
Inferred from Electronic Annotation
more info
 
dopamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
fear response IEA
Inferred from Electronic Annotation
more info
 
fear response ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
homoiothermy IEA
Inferred from Electronic Annotation
more info
 
homoiothermy ISO
Inferred from Sequence Orthology
more info
 
leukocyte mediated immunity IEA
Inferred from Electronic Annotation
more info
 
leukocyte mediated immunity ISO
Inferred from Sequence Orthology
more info
 
leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
maternal behavior ISO
Inferred from Sequence Orthology
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
memory ISO
Inferred from Sequence Orthology
more info
 
multicellular organism aging IEP
Inferred from Expression Pattern
more info
PubMed 
norepinephrine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
norepinephrine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
norepinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
norepinephrine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
octopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine ISO
Inferred from Sequence Orthology
more info
 
response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to iron ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to isolation stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 
response to ozone IEP
Inferred from Expression Pattern
more info
PubMed 
response to pain IEA
Inferred from Electronic Annotation
more info
 
response to pain ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of taste IEP
Inferred from Expression Pattern
more info
PubMed 
social behavior IEP
Inferred from Expression Pattern
more info
PubMed 
visual learning IEA
Inferred from Electronic Annotation
more info
 
visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
chromaffin granule lumen IEA
Inferred from Electronic Annotation
more info
 
chromaffin granule membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic, membrane-bounded vesicle IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
varicosity IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dopamine beta-hydroxylase
Names
Dopamine beta hydroxylase (dopamine beta-monooxygenase)
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
dopamine beta-monooxygenase
NP_037290.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013158.2NP_037290.2  dopamine beta-hydroxylase

    Status: VALIDATED

    Source sequence(s)
    BF525224, L12407
    UniProtKB/Swiss-Prot
    Q05754
    Related
    ENSRNOP00000057915, ENSRNOT00000061201
    Conserved Domains (3) summary
    cd09631
    Location:54172
    DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins
    pfam01082
    Location:217346
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:362520
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    5709236..5731895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    5285082..5302054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)