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Igfbp1 insulin-like growth factor binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25685, updated on 17-May-2016
Official Symbol
Igfbp1provided by RGD
Official Full Name
insulin-like growth factor binding protein 1provided by RGD
Primary source
RGD:2872
See related
Ensembl:ENSRNOG00000058780
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
IBP1; IGFBA; IGF-BP25
Summary
a modulator of a Insulin growth factor (IGF) bioavailability [RGD, Feb 2006]
Orthologs
Location:
14q21
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (87448716..87453783)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (81083056..81088123)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 1 (brain) Neighboring gene uncharacterized LOC102553858 Neighboring gene insulin-like growth factor binding protein 3 Neighboring gene uncharacterized LOC103693169

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
 
insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
 
insulin-like growth factor II binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
insulin receptor signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell growth IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
tissue regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
insulin-like growth factor-binding protein 1
Names
IBP-1
IGF-binding protein 1
IGFBP-1
placental protein 12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013144.1NP_037276.1  insulin-like growth factor-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_037276.1

    Status: PROVISIONAL

    Source sequence(s)
    M58634
    UniProtKB/Swiss-Prot
    P21743
    Related
    ENSRNOP00000069247, ENSRNOT00000077177
    Conserved Domains (2) summary
    smart00121
    Location:30107
    IB; Insulin growth factor-binding protein homologues
    cd00191
    Location:188264
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    87448716..87453783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    81092381..81126760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)