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Gckr glucokinase (hexokinase 4) regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 25658, updated on 26-May-2016
Official Symbol
Gckrprovided by RGD
Official Full Name
glucokinase (hexokinase 4) regulatorprovided by RGD
Primary source
RGD:2671
See related
Ensembl:ENSRNOG00000048874 Vega:OTTRNOG00000000914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
GLRE
Summary
inhibits the activity of glucokinase; plays a role in glucose metabolism and homeostasis [RGD, Feb 2006]
Orthologs
Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26355296..26385761, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (36175967..36205241, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 4930548H24 Neighboring gene zinc finger protein 512 Neighboring gene titin-like Neighboring gene uncharacterized LOC100910821 Neighboring gene intraflagellar transport 172 Neighboring gene dihydropyrimidinase-related protein 5-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC93611

Gene Ontology Provided by RGD

Function Evidence Code Pubs
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enzyme binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
fructose-6-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
fructose-6-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
detection of glucose NAS
Non-traceable Author Statement
more info
PubMed 
glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucokinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
protein import into nucleus, translocation IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
response to fructose IDA
Inferred from Direct Assay
more info
PubMed 
response to fructose ISO
Inferred from Sequence Orthology
more info
 
triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
urate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
glucokinase regulatory protein
Names
glucokinase regulator

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013120.2NP_037252.1  glucokinase regulatory protein

    See identical proteins and their annotated locations for NP_037252.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081843
    UniProtKB/Swiss-Prot
    Q07071
    Related
    ENSRNOP00000064260, OTTRNOP00000000756, ENSRNOT00000073228, OTTRNOT00000001393
    Conserved Domains (2) summary
    PRK05441
    Location:293605
    murQ; N-acetylmuramic acid-6-phosphate etherase; Reviewed
    cl00389
    Location:109273
    SIS; SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    26355296..26385761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    24538242..24568355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)