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Krt8 keratin 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25626, updated on 26-May-2016
Official Symbol
Krt8provided by RGD
Official Full Name
keratin 8provided by RGD
Primary source
RGD:2984
See related
Ensembl:ENSRNOG00000009779 Vega:OTTRNOG00000001600
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
CYKER; Krt2-8
Summary
an intermediate filament protein; may play a role in prostrate cells [RGD, Feb 2006]
Orthologs
Location:
7q36
Exon count:
9
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143596511..143603745, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (141393004..141400457, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene keratin 78 Neighboring gene cysteine-rich PDZ-binding protein pseudogene Neighboring gene keratin 18 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC102557354

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation involved in embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
response to hydrostatic pressure IDA
Inferred from Direct Assay
more info
PubMed 
response to other organism IEA
Inferred from Electronic Annotation
more info
 
response to other organism ISO
Inferred from Sequence Orthology
more info
 
sarcomere organization IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
Z disc ISO
Inferred from Sequence Orthology
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
costamere IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dystrophin-associated glycoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
intermediate filament ISO
Inferred from Sequence Orthology
more info
 
keratin filament IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
keratin, type II cytoskeletal 8
Names
CK-8
K8
cytokeratin endo A
cytokeratin-8
keratin 8, type II
keratin complex 2, basic, gene 8
keratin-8
type-II keratin Kb8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199370.1NP_955402.1  keratin, type II cytoskeletal 8

    See identical proteins and their annotated locations for NP_955402.1

    Status: PROVISIONAL

    Source sequence(s)
    AY464139
    UniProtKB/Swiss-Prot
    Q10758
    Related
    ENSRNOP00000029068, OTTRNOP00000001446, ENSRNOT00000038480, OTTRNOT00000002519
    Conserved Domains (2) summary
    pfam00038
    Location:90401
    Filament; Intermediate filament protein
    TIGR03495
    Location:282358
    phage_LysB; phage lysis regulatory protein, LysB family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    143596511..143603745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    129561335..129568866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)