Acadsb acyl-CoA dehydrogenase, short/branched chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Acadsbprovided by RGD
Full Name: acyl-CoA dehydrogenase, short/branched chainprovided by RGD
Primary source: RGD:2013
See related: Ensembl:ENSRNOG00000020624 AllianceGenome:RGD:2013
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables electron transfer activity and short-branched-chain-acyl-CoA dehydrogenase activity. Acts upstream of or within acyl-CoA metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 400.3), Kidney (RPKM 320.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (195619088..195660564)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (186188939..186227796)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (201981362..202022771)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Short/branched chain acyl-CoA dehydrogenase has its catalytic properties relatively similar to those of straight-chain acyl-CoA dehydrogenases in terms of their isomerase activity and enzyme inhibition.
Title: Comparative studies of Acyl-CoA dehydrogenases for monomethyl branched chain substrates in amino acid metabolism.
Differences between the rat and human enzyme at positions 383, 222, and 220 alter substrate specificity without affecting substrate binding.
Title: A novel approach to the characterization of substrate specificity in short/branched chain Acyl-CoA dehydrogenase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-methylbutanoyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 2-methylbutanoyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 2-methylbutanoyl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 2-methylpropanoyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables butyryl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables short-chain fatty acyl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables short-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carboxylic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in isoleucine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoleucine catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

Names: 2-MEBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; Acyl-Coenzyme A dehydrogenase short-branched chain; SBCAD; acyl-Coenzyme A dehydrogenase, short/branched chain

NP_037216.1

EC 1.3.8.5

XP_008758088.1

EC 1.3.8.5

XP_063138171.1

EC 1.3.8.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013084.2 → NP_037216.1 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

See identical proteins and their annotated locations for NP_037216.1

Status: PROVISIONAL

Source sequence(s)

U64451

UniProtKB/Swiss-Prot

P70584

UniProtKB/TrEMBL

A0A8I6GLN2, A6HWW9

Related

ENSRNOP00000092354.1, ENSRNOT00000112423.1

Conserved Domains (2) summary

cd01158
Location:59 → 430

SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases

COG1960
Location:57 → 428

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

195619088..195660564

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282101.1 → XP_063138171.1 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1
XM_008759866.4 → XP_008758088.1 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I6G5Q8

Conserved Domains (2) summary

cd01158
Location:59 → 409

SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases

COG1960
Location:57 → 409

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]