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Map3k12 mitogen activated protein kinase kinase kinase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25579, updated on 8-May-2016
Official Symbol
Map3k12provided by RGD
Official Full Name
mitogen activated protein kinase kinase kinase 12provided by RGD
Primary source
RGD:3988
See related
Ensembl:ENSRNOG00000015134
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
PK; DLK; MUK; Zpk
Summary
kinase which is an activator of the JNK-pathway [RGD, Feb 2006]
Orthologs
Location:
7q36
Exon count:
17
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144102153..144120306, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (141894406..141912301, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene proline rich 13 Neighboring gene poly(rC) binding protein 2 Neighboring gene TAR (HIV-1) RNA binding protein 2 Neighboring gene neuropeptide FF-amide peptide precursor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
JNK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
histone phosphorylation IEA
Inferred from Electronic Annotation
more info
 
histone phosphorylation ISO
Inferred from Sequence Orthology
more info
 
histone phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
mitophagy in response to mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
mitophagy in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of motor neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
mitogen-activated protein kinase kinase kinase 12
Names
MAPK-upstream kinase
Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase)
Zipper (leucine) protein kinase
dual leucine zipper bearing kinase
dual leucine zipper kinase
leucine-zipper protein kinase
mixed lineage kinase
NP_037187.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013055.1NP_037187.1  mitogen-activated protein kinase kinase kinase 12

    See identical proteins and their annotated locations for NP_037187.1

    Status: PROVISIONAL

    Source sequence(s)
    D49785
    UniProtKB/Swiss-Prot
    Q63796
    Conserved Domains (2) summary
    smart00219
    Location:165397
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:164400
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    144102153..144120306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242382.2XP_006242444.1  

    See identical proteins and their annotated locations for XP_006242444.1

    UniProtKB/TrEMBL
    F1LQ89
    Conserved Domains (2) summary
    smart00219
    Location:165397
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:164400
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  2. XM_006242381.2XP_006242443.1  

    See identical proteins and their annotated locations for XP_006242443.1

    UniProtKB/TrEMBL
    F1LQ89
    Conserved Domains (2) summary
    smart00219
    Location:165397
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:164400
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  3. XM_008765675.1XP_008763897.1  

    Related
    ENSRNOP00000020437, ENSRNOT00000020437
    Conserved Domains (2) summary
    smart00219
    Location:186418
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:185421
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    130056875..130075370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)