Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Tnfrsf4provided by RGD
Official Full Name: tumor necrosis factor receptor superfamily, member 4provided by RGD
Primary source: RGD:3920
See related: Ensembl:ENSRNOG00000020106
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Ox40; Txgp1
Summary: membrane-bound receptor, binds adaptor proteins Traf2 and Traf5; member of the tumor necrosis factor (TNF)-receptor superfamily [RGD, Feb 2006]

Genomic context

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Location :: 5q36

Sequence :: Chromosome: 5; NC_005104.3 (176921804..176924494)

See Tnfrsf4 in MapViewer

Chromosome 5 - NC_005104.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

OX40 and OX40L may play a role in the pathogenesis of experimental allegic neuritis.
Title: [Dynamic change OX40/OX40L mRNA in experimental allergic neuritis].
Ox40-Ox40 ligand is a critical pathway in alloimmune responses, especially recall/primed responses, and is synergistic with CD28-B7 in mediating T cell effector responses during allograft rejection.
Title: The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...

General gene information

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Homology

Homologs of the Tnfrsf4 gene: The Tnfrsf4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and mouse.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
tumor necrosis factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
tumor necrosis factor-activated receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
cellular defense response	ISO Inferred from Sequence Orthology more info
cellular defense response	TAS Traceable Author Statement more info	PubMed
inflammatory response	IEA Inferred from Electronic Annotation more info
inflammatory response	ISO Inferred from Sequence Orthology more info
negative regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of cytokine secretion	IEA Inferred from Electronic Annotation more info
negative regulation of cytokine secretion	ISO Inferred from Sequence Orthology more info
negative regulation of sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
negative regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of immunoglobulin secretion	ISO Inferred from Sequence Orthology more info
regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info
regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 4

Names: tumor necrosis factor receptor superfamily member 4; MRC OX40; OX40 antigen; OX40L receptor; tumor necrosis factor superfamily, member 4; Tax-transcriptionally activated glycoprotein 1; tumor necrosis factor (ligand) superfamily member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013049.1 → NP_037181.1 tumor necrosis factor receptor superfamily member 4 precursor

Status: PROVISIONAL

Source sequence(s)

X17037

UniProtKB/Swiss-Prot

P15725

Related

ENSRNOP00000027251, ENSRNOT00000027251

Conserved Domains (1) summary

cd00185
Location:28 – 126
Blast Score: 197

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

NC_005104.3 Reference Rnor_5.0 Primary Assembly

Range

176921804..176924494

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

AC_000073.1 Alternate Rn_Celera

Range

164807766..164810456

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GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AABR06041319.1 (319912..322602)	None
genomic	AAHX01041236.1 (14280..16970)	None
genomic	CH473968.1	EDL81353.1
mRNA	X17037.1	CAA34897.1	PVG/DA