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Slc6a4 solute carrier family 6 member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25553, updated on 17-May-2016
Official Symbol
Slc6a4provided by RGD
Official Full Name
solute carrier family 6 member 4provided by RGD
Primary source
RGD:3714
See related
Ensembl:ENSRNOG00000003476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
SERT
Summary
binds serotonin; may play a role in regulation of motor activity [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Orthologs
Location:
10q26
Exon count:
14
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63153656..63186439, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (62851326..62872481, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 5 Neighboring gene microRNA 423 Neighboring gene nuclear speckle splicing regulatory protein 1 Neighboring gene bleomycin hydrolase Neighboring gene transmembrane and immunoglobulin domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Rab GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
cocaine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monoamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
myosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
nitric-oxide synthase binding IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
serotonin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
serotonin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
serotonin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
serotonin transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
serotonin transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
serotonin:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
serotonin:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
syntaxin-1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
brain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
brain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to cGMP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior NAS
Non-traceable Author Statement
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
monoamine transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cerebellar granule cell precursor proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
serotonin transport IDA
Inferred from Direct Assay
more info
PubMed 
serotonin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
serotonin transport ISO
Inferred from Sequence Orthology
more info
 
serotonin transport TAS
Traceable Author Statement
more info
PubMed 
serotonin uptake IDA
Inferred from Direct Assay
more info
PubMed 
serotonin uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
serotonin uptake ISO
Inferred from Sequence Orthology
more info
 
social behavior IEA
Inferred from Electronic Annotation
more info
 
social behavior ISO
Inferred from Sequence Orthology
more info
 
sperm ejaculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
thalamus development IEA
Inferred from Electronic Annotation
more info
 
thalamus development ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system ISO
Inferred from Sequence Orthology
more info
 
endomembrane system NAS
Non-traceable Author Statement
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
sodium-dependent serotonin transporter
Names
5HT transporter
5HTT
Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
serotonin transporter
solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
solute carrier family 6 (neurotransmitter transporter), member 4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
solute carrier family 6, member 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013034.4NP_037166.2  sodium-dependent serotonin transporter

    See identical proteins and their annotated locations for NP_037166.2

    Status: VALIDATED

    Source sequence(s)
    AC128611, AI547408, BF548147, CB736426, M79450
    UniProtKB/Swiss-Prot
    P31652
    Related
    ENSRNOP00000004717, ENSRNOT00000004717
    Conserved Domains (2) summary
    pfam03491
    Location:2364
    5HT_transporter; Serotonin (5-HT) neurotransmitter transporter, N-terminus
    cd11513
    Location:79615
    SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    63153656..63186439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767950.1XP_008766172.1  

    See identical proteins and their annotated locations for XP_008766172.1

    UniProtKB/Swiss-Prot
    P31652
    Conserved Domains (2) summary
    pfam03491
    Location:2364
    5HT_transporter; Serotonin (5-HT) neurotransmitter transporter, N-terminus
    cd11513
    Location:79615
    SLC6sbd_SERT; Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    60845942..60866725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)