Oaz1 ornithine decarboxylase antizyme 1 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Oaz1provided by RGD
Official Full Name: ornithine decarboxylase antizyme 1provided by RGD
Primary source: RGD:3219
See related: Ensembl:ENSRNOG00000019459
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Oaz; ODCAC; ODC-Az
Summary: Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 7q11

Sequence :: Chromosome: 7; NC_005106.2 (10394495..10396952, complement)

See Oaz1 in MapViewer

Chromosome 7 - NC_005106.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Corticosterone treatment induces antizyme 1 protein synthesis in early regenerating rat liver. However, it has little effect on antizyme 1 gene transcription.
Title: The influence of corticosterone on antizyme gene expression in early regenerating rat liver.
overexpression of ornithine decarboxylase antizyme 1 is necessary for conversion of pancreatic tumor cells into glucagon-producing differentiated cells.
Title: Antizyme is necessary for conversion of pancreatic tumor cells into glucagon-producing differentiated cells.
ability of antizyme 1 to shuttle between the nucleus and the cytoplasm suggests that it has a novel function in the nucleus
Title: Identification of nuclear export signals in antizyme-1.
Degradation of antizyme requires a functional ubiquitin system.
Title: Ornithine decarboxylase-antizyme is rapidly degraded through a mechanism that requires functional ubiquitin-dependent proteolytic activity.
NMR study of the solution structure of a stable, folded domain of antizyme isoform-1 consisting of amino acid residues 87-227; it contains eight beta strands & two alpha helices with the strands forming a mixed parallel & antiparallel beta sheet
Title: Solution structure of a conserved domain of antizyme: a protein regulator of polyamines.
The antizyme 1-mediated pathway for cyclin D1 degradation is independent of the previously characterized phosphorylation- and ubiquitination-dependent pathway
Title: Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression.
antizyme expression requires programmed, ribosomal frameshifting
Title: Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:247534	BioGRID:107067	CCND1		BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
ornithine decarboxylase inhibitor activity	IEA Inferred from Electronic Annotation more info
ornithine decarboxylase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: ornithine decarboxylase antizyme 1

Names: ornithine decarboxylase antizyme 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139081.1 → NP_620781.1 ornithine decarboxylase antizyme 1

Status: REVIEWED

Source sequence(s)

D10706, D11372

UniProtKB/Swiss-Prot

P54370

Related

ENSRNOP00000026341, ENSRNOT00000026341

Conserved Domains (1) summary

pfam02100
Location:122 – 218
Blast Score: 378

ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005106.2 Reference assembly (based on RGSC_v3.4)

Range

10394495..10396952, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000075.1 Alternate assembly (Rn_Celera)

Range

7067978..7070435, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CH474029.1	EDL89222.1
		EDL89223.1
		EDL89224.1
		EDL89225.1
		EDL89226.1
genomic	D11372.1	None	Sprague-Dawley
mRNA	BC088441.1	None
mRNA	BC158783.1	None
mRNA	D10706.1	BAA01549.1	Sprague-Dawley
		BAA01550.1	Sprague-Dawley
		BAA01551.1	Sprague-Dawley