Irs1 insulin receptor substrate 1 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Irs1provided by RGD
Official Full Name: insulin receptor substrate 1provided by RGD
Primary source: RGD:2922
See related: Ensembl:ENSRNOG00000014597
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: IRS1IRM
Summary: a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism [RGD, Feb 2006]
Annotation information: Annotation category: partial on reference assembly

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Genomic context

Location :: 9q34

Sequence :: Chromosome: 9; NC_005108.2 (81585251..81638071, complement)

See Irs1 in MapViewer

Chromosome 9 - NC_005108.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings suggest that improvements in glucose tolerance and insulin resistance following Roux-en-Y gastric bypass surgery are associated with upregulation of IRS-1.
Title: Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes?
Foxo1 protein was excluded from the nuclei in L6-mIRS1 cells, whereas Foxo1 was localized in the nuclei in control L6 cells during induction of differentiation.
Title: Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts.
We conclude that phosphorylation of Ser307, Ser302, and Ser632 of IRS-1 is not involved in ANG II-mediated IRS-1 degradation
Title: Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK.
sex steroid deficiency induces impaired glucose oxidation in insulin responsive tissues, which is mediated through reduced IR expression, and increased IRS-1 serine phosphorylation
Title: Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat.
Our findings suggest an interaction between vitamin D(3) and muscarinic M3 receptors in regulating insulin secretion from pancreas.
Title: Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats.
Protein, but not mRNA levels of IRS1, was decreased only in the glomeruli of streptozotocin-diabetic rats likely due to increased ubiquitination.
Title: Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.
resistin induces cardiac hypertrophy and myocardial insulin resistance, possibly via the AMPK/mTOR/p70(S6K) and apoptosis signal-regulating kinase 1/JNK/IRS1 pathways.
Title: Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways.
Adiponectin receptors and IRS1 might be crucially important regulators for the synthesis and oxidation of fatty acids in the liver of Nonalcoholic steatohepatitis
Title: Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model.
iNOS-mediated tyrosine nitration of IRS-1 is a key mechanism of skeletal muscle insulin resistance in endotoxemia
Title: Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle.
Over-expression of NYGGF4 inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3K/AKT insulin pathway
Title: Over-expression of NYGGF4 (PID1) inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3K/AKT insulin pathway.

Submit: New GeneRIF Correction See all (81)

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:247500	BioGRID:272292	Cbl	BioGRID	PubMed	Affinity Capture-Western
BioGRID:247500	BioGRID:260847	Mdm2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:247500	BioGRID:247545	Pik3r1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:247500	BioGRID:248353	Pik3r2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:247500	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:247500	BioGRID:248372	Ubc	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
insulin receptor binding	IEA Inferred from Electronic Annotation more info
insulin receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
insulin receptor binding	ISO Inferred from Sequence Orthology more info
insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
insulin-like growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
insulin-like growth factor-activated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
phosphatidylinositol 3-kinase binding	IDA Inferred from Direct Assay more info	PubMed
phosphatidylinositol 3-kinase binding	IMP Inferred from Mutant Phenotype more info	PubMed
phosphatidylinositol 3-kinase binding	IPI Inferred from Physical Interaction more info	PubMed
phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	ISO Inferred from Sequence Orthology more info
receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT insulin secretion	ISO Inferred from Sequence Orthology more info
insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
insulin-like growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
lipid catabolic process	IEA Inferred from Electronic Annotation more info
lipid catabolic process	ISO Inferred from Sequence Orthology more info
mammary gland development	IEA Inferred from Electronic Annotation more info
mammary gland development	ISO Inferred from Sequence Orthology more info
negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
negative regulation of somatostatin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
phosphatidylinositol 3-kinase cascade	IEA Inferred from Electronic Annotation more info
phosphatidylinositol 3-kinase cascade	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
positive regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
positive regulation of glucagon secretion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of glucose import	IEA Inferred from Electronic Annotation more info
positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
positive regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
positive regulation of glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of phosphatidylinositol 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphatidylinositol 3-kinase activity	ISO Inferred from Sequence Orthology more info
positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein heterooligomerization	IDA Inferred from Direct Assay more info	PubMed
protein kinase B signaling cascade	IEA Inferred from Electronic Annotation more info
protein kinase B signaling cascade	ISO Inferred from Sequence Orthology more info
protein localization to nucleus	IEA Inferred from Electronic Annotation more info
protein localization to nucleus	ISO Inferred from Sequence Orthology more info
regulation of gene expression	IEA Inferred from Electronic Annotation more info
regulation of gene expression	ISO Inferred from Sequence Orthology more info
response to insulin stimulus	ISO Inferred from Sequence Orthology more info
response to peptide hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
caveola	IEA Inferred from Electronic Annotation more info
caveola	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
insulin receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
microsome	IDA Inferred from Direct Assay more info	PubMed
microsome	ISO Inferred from Sequence Orthology more info
microsome	ISS Inferred from Sequence or Structural Similarity more info
nucleus	ISO Inferred from Sequence Orthology more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: insulin receptor substrate 1

Names: insulin receptor substrate 1; IRS-1; pp185

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012969.1 → NP_037101.1 insulin receptor substrate 1

Status: PROVISIONAL

Source sequence(s)

X58375

UniProtKB/Swiss-Prot

P35570

Related

ENSRNOP00000019579, ENSRNOT00000019579

Conserved Domains (2) summary

cd01204
Location:155 – 258
Blast Score: 537

IRS_PTB; Insulin receptor substrate (IRS) Phosphotyrosine-binding domain(PTB)

cd01257
Location:12 – 113
Blast Score: 496

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain