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MCM9 minichromosome maintenance 9 homologous recombination repair factor [ Homo sapiens (human) ]

Gene ID: 254394, updated on 26-May-2016
Official Symbol
MCM9provided by HGNC
Official Full Name
minichromosome maintenance 9 homologous recombination repair factorprovided by HGNC
Primary source
HGNC:HGNC:21484
See related
Ensembl:ENSG00000111877 HPRD:17472; MIM:610098; Vega:OTTHUMG00000015468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODG4; MCMDC1; C6orf61; dJ329L24.1; dJ329L24.3
Summary
The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
Orthologs
Location:
6q22.31
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (118813449..118935162, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (119134612..119256327, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 like Neighboring gene uncharacterized LOC105377969 Neighboring gene selenoprotein K pseudogene Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184 member A Neighboring gene microRNA 548b Neighboring gene uncharacterized LOC105377974 Neighboring gene mannosidase alpha class 1A member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell cycle, organism-specific biosystem (from WikiPathways)
    Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13942, FLJ20170, FLJ56845, MGC35304

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
female gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
MCM8-MCM9 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
DNA helicase MCM9
Names
DNA replication licensing factor MCM9
mini-chromosome maintenance deficient domain-containing protein 1
minichromosome maintenance complex component 9
NP_060166.2
NP_694987.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041822.1 RefSeqGene

    Range
    8425..126714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017696.2NP_060166.2  DNA helicase MCM9 isoform 1

    See identical proteins and their annotated locations for NP_060166.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL132874, AL359634, BN000882
    Consensus CDS
    CCDS56447.1
    UniProtKB/Swiss-Prot
    Q9NXL9
    Related
    ENSP00000480469, ENST00000619706
    Conserved Domains (3) summary
    cd00009
    Location:346489
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00350
    Location:116603
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:37128
    MCM_N; MCM N-terminal domain
  2. NM_153255.4NP_694987.1  DNA helicase MCM9 isoform 2

    See identical proteins and their annotated locations for NP_694987.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal exon and lacks 6 exons in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL132874, BC024976, BC031658, DB453085
    Consensus CDS
    CCDS5121.1
    UniProtKB/Swiss-Prot
    Q9NXL9
    UniProtKB/TrEMBL
    A0A0S2Z662
    Related
    ENSP00000312870, OTTHUMP00000017098, ENST00000316068, OTTHUMT00000042004
    Conserved Domains (3) summary
    COG1241
    Location:10385
    Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
    pfam14551
    Location:37128
    MCM_N; MCM N-terminal domain
    cl21455
    Location:347375
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    118813449..118935162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    119398623..119520384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)