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Hbegf heparin-binding EGF-like growth factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25433, updated on 8-May-2016
Official Symbol
Hbegfprovided by RGD
Official Full Name
heparin-binding EGF-like growth factorprovided by RGD
Primary source
RGD:2526
See related
Ensembl:ENSRNOG00000018646
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Dtr; GFHB; Hegfl; Hb-egf
Summary
activates epidermal growth factor receptor mediated signaling; contributes to neuronal survival; may play a role in neurogenesis during ventral midbrain development [RGD, Feb 2006]
Orthologs
Location:
18p11
Exon count:
6
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29330302..29340185, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (29036863..29046746, complement)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene cysteine-rich transmembrane module containing 1 Neighboring gene prefoldin subunit 1 Neighboring gene solute carrier family 4 member 9 Neighboring gene ankyrin repeat and KH domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
epidermal growth factor receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of elastin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of keratinocyte migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of wound healing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
wound healing, spreading of epidermal cells IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
proheparin-binding EGF-like growth factor
Names
Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)
heparin binding epidermal growth factor-like growth factor
heparin-binding epidermal -growth - like growth factor
heparin-binding epidermal -growth factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012945.1NP_037077.1  proheparin-binding EGF-like growth factor precursor

    See identical proteins and their annotated locations for NP_037077.1

    Status: PROVISIONAL

    Source sequence(s)
    L05489
    UniProtKB/Swiss-Prot
    Q06175
    Related
    ENSRNOP00000025157, ENSRNOT00000025157
    Conserved Domains (1) summary
    PHA02887
    Location:108148
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    29330302..29340185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    27834537..27844179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)