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SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 [ Homo sapiens (human) ]

Gene ID: 2542, updated on 6-Jul-2014
Official Symbol
SLC37A4provided by HGNC
Official Full Name
solute carrier family 37 (glucose-6-phosphate transporter), member 4provided by HGNC
Primary source
HGNC:4061
Locus tag
PRO0685
See related
Ensembl:ENSG00000137700; HPRD:04052; MIM:602671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
Summary
This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
See SLC37A4 in Epigenomics, MapViewer
Location:
11q23.3
Exon count :
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (119024351..119030906, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118895061..118901616, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 84 Neighboring gene ribosomal protein S25 Neighboring gene trafficking protein particle complex 4 Neighboring gene microRNA 3656 Neighboring gene hypoxia up-regulated 1 Neighboring gene vacuolar protein sorting 11 homolog (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Carbohydrate digestion and absorption, organism-specific biosystem (from KEGG)
    Carbohydrate digestion and absorption, organism-specific biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
  • Carbohydrate digestion and absorption, conserved biosystem (from KEGG)
    Carbohydrate digestion and absorption, conserved biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Glucose transport, organism-specific biosystem (from REACTOME)
    Glucose transport, organism-specific biosystemCells take up glucose by facilitated diffusion, via glucose transporters (GLUTs) associated with the plasma membrane, a reversible reaction (Joost and Thorens 2001). Four tissue-specific GLUT isoform...
  • Glycogen storage diseases, organism-specific biosystem (from REACTOME)
    Glycogen storage diseases, organism-specific biosystemThe regulated turnover of glycogen plays a central, tissue-specific role in the maintenance of blood glucose levels and in the provision of glucose to tissues such as muscle and brain in response to ...
  • Hexose transport, organism-specific biosystem (from REACTOME)
    Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Myoclonic epilepsy of Lafora, organism-specific biosystem (from REACTOME)
    Myoclonic epilepsy of Lafora, organism-specific biosystemLafora disease is a progressive neurodegenerative disorder with onset typically late in childhood, characterized by seizures and progressive neurological deterioration and death within ten years of o...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucose-6-phosphate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
glucose-6-phosphate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process TAS
Traceable Author Statement
more info
 
glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
glucose metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
glucose transport TAS
Traceable Author Statement
more info
 
glucose-6-phosphate transport IDA
Inferred from Direct Assay
more info
PubMed 
glucose-6-phosphate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
hexose transport TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
glucose-6-phosphate translocase
Names
glucose-6-phosphate translocase
glucose-5-phosphate transporter
solute carrier family 37 member 4
transformation-related gene 19 protein
microsomal glucose-6-phosphate transporter
glucose-6-phosphatase, transport (glucose) protein 3
glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013331.1 

    Range
    5001..11555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_187

mRNA and Protein(s)

  1. NM_001164277.1NP_001157749.1  glucose-6-phosphate translocase isoform 1

    See proteins identical to NP_001157749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript variant. Variants 1, 4, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AK289642, AP003392, BC015650, BM506735, DC295438
    UniProtKB/TrEMBL
    A8K0S7
    UniProtKB/Swiss-Prot
    O43826
    Related
    ENSP00000475241, ENST00000545985
    Conserved Domains (2) summary
    cd06174
    Location:14415
    Blast Score: 330
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00881
    Location:18397
    Blast Score: 1107
    2A0104; phosphoglycerate transporter family protein
  2. NM_001164278.1NP_001157750.1  glucose-6-phosphate translocase isoform 2

    See proteins identical to NP_001157750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK312628, AP003392, BC014663, BC064563, BM506735, DC295438
    UniProtKB/Swiss-Prot
    O43826
    Related
    ENSP00000476176, ENST00000357590
    Conserved Domains (2) summary
    cd06174
    Location:14437
    Blast Score: 318
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00881
    Location:18419
    Blast Score: 1087
    2A0104; phosphoglycerate transporter family protein
  3. NM_001164279.1NP_001157751.1  glucose-6-phosphate translocase isoform 3

    See proteins identical to NP_001157751.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK300646, BC064563, BM506735, DC295438
    UniProtKB/TrEMBL
    B4DUH2
    UniProtKB/Swiss-Prot
    O43826
    Related
    ENSP00000475991, ENST00000538950
    Conserved Domains (1) summary
    cd06174
    Location:4342
    Blast Score: 249
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  4. NM_001164280.1NP_001157752.1  glucose-6-phosphate translocase isoform 1

    See proteins identical to NP_001157752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    BC002400, BC064563, BM506735
    UniProtKB/Swiss-Prot
    O43826
    Conserved Domains (2) summary
    cd06174
    Location:14415
    Blast Score: 330
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00881
    Location:18397
    Blast Score: 1107
    2A0104; phosphoglycerate transporter family protein
  5. NM_001467.5NP_001458.1  glucose-6-phosphate translocase isoform 1

    See proteins identical to NP_001458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    BC014663, BM506735, DC295438
    UniProtKB/Swiss-Prot
    O43826
    Conserved Domains (2) summary
    cd06174
    Location:14415
    Blast Score: 330
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00881
    Location:18397
    Blast Score: 1107
    2A0104; phosphoglycerate transporter family protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    119024351..119030906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    114834720..114841274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    118781352..118787906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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