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Crp C-reactive protein, pentraxin-related [ Rattus norvegicus (Norway rat) ]

Gene ID: 25419, updated on 8-May-2016
Official Symbol
Crpprovided by RGD
Official Full Name
C-reactive protein, pentraxin-relatedprovided by RGD
Primary source
RGD:2411
See related
Ensembl:ENSRNOG00000000053
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Aa1249; Ac1262; Ab1-341; Ab2-196; Ac1-114; Ac2-069; Ba2-693
Summary
glycoprotein of the acute phase response [RGD, Feb 2006]
Orthologs
Location:
13q24
Exon count:
2
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (91080448..91081358)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (95599418..95600328)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene Fc receptor-like 6 Neighboring gene dual specificity phosphatase 23 Neighboring gene Fc fragment of IgG, low affinity IIa, receptor Neighboring gene Fc gamma receptor II beta

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
complement component C1q binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT virion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nitric oxide IEP
Inferred from Expression Pattern
more info
PubMed 
complement activation, classical pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
protein polymerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-8 secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of interleukin-8 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
C-reactive protein
Names
C-reactive protein member of the pentraxin family
C-reactive protein, member of the pentraxin family
C-reactive protein, petaxin related

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017096.3NP_058792.1  C-reactive protein precursor

    See identical proteins and their annotated locations for NP_058792.1

    Status: PROVISIONAL

    Source sequence(s)
    M83176
    UniProtKB/Swiss-Prot
    P48199
    UniProtKB/TrEMBL
    H6X2W5
    Related
    ENSRNOP00000000058, ENSRNOT00000000058
    Conserved Domains (1) summary
    cd00152
    Location:20218
    PTX; Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    91080448..91081358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    84770843..84771753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)