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lcf1 long-chain-fatty-acid-CoA ligase Lcf1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540731, updated on 7-Apr-2024

Summary

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Gene symbol
lcf1
Gene description
long-chain-fatty-acid-CoA ligase Lcf1
Primary source
PomBase:SPBC18H10.02
Locus tag
SPBC18H10.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (1769946..1772629)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene Sm snRNP core protein Sme1 Neighboring gene putative DNA-directed RNA polymerase I complex subunit Rpa34 Neighboring gene putative karyopherin Mtr10 Neighboring gene miscRNA Neighboring gene translation initiation factor eIF3g Neighboring gene tRNA-Trp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A defect in a fatty acyl-CoA synthetase gene, lcf1+, results in a decrease in viability after entry into the stationary phase in fission yeast. Oshiro T, et al. Mol Genet Genomics, 2003 Jul. PMID 12684881
  2. Identification of a fatty acyl-CoA synthetase gene, lcf2+, which affects viability after entry into the stationary phase in Schizosaccharomyces pombe. Fujita Y, et al. Biosci Biotechnol Biochem, 2007 Dec. PMID 18071249
  3. Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast. Nguyen TT, et al. Sci Rep, 2015 Feb 11. PMID 25669599, Free PMC Article
  4. A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast. Mathiassen SG, et al. J Biol Chem, 2015 Aug 21. PMID 26152728, Free PMC Article
  5. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IC
Inferred by Curator
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myristoyl-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oleoyl-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables palmitoyl-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in long-chain fatty-acyl-CoA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid-CoA ligase Lcf1
NP_595726.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1769946..1772629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021624.2 → NP_595726.1  long-chain-fatty-acid-CoA ligase Lcf1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595726.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O60135
    Conserved Domains (2) summary
    cd05927
    Location:92 → 674
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    COG1022
    Location:50 → 676
    FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
Nucleotide Protein
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