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Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25399, updated on 17-May-2016
Official Symbol
Cacna2d1provided by RGD
Official Full Name
calcium voltage-gated channel auxiliary subunit alpha2delta 1provided by RGD
Primary source
RGD:2247
See related
Ensembl:ENSRNOG00000033531
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
CCHLA2; Cacna2; DHSCCA
Summary
subunit of voltage-gated calcium channels; contributes to the regulation of N- and/or L-type calcium channels [RGD, Feb 2006]
Orthologs
Location:
4q11
Exon count:
40
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (15706974..16130848, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (15681399..16105483, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene cadherin EGF LAG seven-pass G-type receptor 2-like Neighboring gene uncharacterized LOC103692033 Neighboring gene hepatocyte growth factor Neighboring gene uncharacterized LOC103692034 Neighboring gene hypothetical LOC100360215 Neighboring gene piccolo (presynaptic cytomatrix protein)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adrenaline,noradrenaline inhibits insulin secretion, organism-specific biosystem (from REACTOME)
    Adrenaline,noradrenaline inhibits insulin secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
    Regulation of insulin secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
L-type voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
L-type voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
 
L-type voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
T-tubule ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
voltage-dependent calcium channel subunit alpha-2/delta-1
Names
Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)
calcium channel, voltage-dependent, alpha2/delta subunit 1
voltage-gated calcium channel subunit alpha-2/delta-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110847.1NP_001104317.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001104317.1

    Status: PROVISIONAL

    Source sequence(s)
    AF400662
    UniProtKB/TrEMBL
    Q8VHS9
    Conserved Domains (5) summary
    pfam08473
    Location:538628
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446530
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    cl21471
    Location:537804
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
  2. NM_001110848.1NP_001104318.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001104318.1

    Status: PROVISIONAL

    Source sequence(s)
    AF486276
    UniProtKB/TrEMBL
    Q8CFG7
    Related
    ENSRNOP00000074171, ENSRNOT00000090240
    Conserved Domains (5) summary
    pfam08473
    Location:543633
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446531
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    cl21471
    Location:623809
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
  3. NM_012919.3NP_037051.2  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_037051.2

    Status: PROVISIONAL

    Source sequence(s)
    AF286488
    UniProtKB/TrEMBL
    Q9ERS3
    Related
    ENSRNOP00000044940, ENSRNOT00000042914
    Conserved Domains (5) summary
    pfam08473
    Location:543636
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446531
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    cl21471
    Location:636816
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    15706974..16130848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235983.2XP_006236045.1  

    Conserved Domains (5) summary
    pfam08473
    Location:538631
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446530
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    cl21471
    Location:631811
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
  2. XM_006235982.2XP_006236044.1  

    Conserved Domains (5) summary
    pfam08473
    Location:562652
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446537
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    cl21471
    Location:561828
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
  3. XM_006235981.2XP_006236043.1  

    Conserved Domains (5) summary
    pfam08473
    Location:562655
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446537
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    cl21471
    Location:655835
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    14480196..14898934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)